Anileridine

Anileridine

Systematic (IUPAC) name
Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	?
Legal status	℞-only (CA) Schedule II (US)
Routes	Tablets, injection
Pharmacokinetic data
Protein binding	> 95%
Metabolism	Hepatic
Identifiers
CAS number	144-14-9 Y
ATC code	N01AH05
PubChem	CID 8944
DrugBank	APRD00741
ChemSpider	8600 Y
UNII	71Q1A3O279 Y
KEGG	D02941 Y
ChEBI	CHEBI:61203 Y
ChEMBL	CHEMBL1201347 N
Chemical data
Formula	C22H28N2O2
Mol. mass	352.47 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 Y Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N Y
Physical data
Melt. point	83 °C (181 °F)
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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s^[1]. It differs from meperidine (Demerol) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.^[2]

Administration

As tablets or injection.^[3]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.^[4] It is mostly metabolized by the liver.

References

1. ^ US Patent 2897204
2. ^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. http://www.pharmacists.ca/content/hcp/tools/drugnews/discontinued.htm. Retrieved 28 July 2008. 
3. ^ "Pharmaceutical Information - LERITINE". RxMed. http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20%28General%20Monographs-%20L%29/LERITINE.html. Retrieved 16 June 2010. 
4. ^ "Anileridine Consumer Information". MedicineNet. http://www.medicinenet.com/anileridine-oral_tablet/article.htm. Retrieved 28 July 2008. 

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.v · Categories: Piperidines Synthetic opioids General anesthetics Anilines Ethyl esters Mu-opioid agonists Nervous system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Popcorn (film) Antifascistisk Aktion Look at other dictionaries: anileridine hydrochloride — [USP] the hydrochloride salt of anileridine; administered orally in the treatment of moderate to severe pain …   Medical dictionary anileridine — noun A particular narcotic painkiller …   Wiktionary anileridine — Analgesic agent related chemically and pharmacologically to meperidine hydrochloride; used for relief of moderate to severe pain; also mildly antihistaminic and spasmolytic; addiction liability is equivalent to that of morphine. * * *… …   Medical dictionary Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia Phencyclidine — Systematic (IUPAC) name …   Wikipedia Oxymorphone — Systematic (IUPAC) name 4,5α epoxy 3,14 dihydroxy 17 methylmorphinan 6 one Clinical data Trade names …   Wikipedia Morphinan — Preferred IUPAC name Morphinan …   Wikipedia Phenoperidine — Systematic (IUPAC) name ethyl 1 (3 hydroxy 3 phenylpropyl) 4 phenylpiperidine 4 carboxylate Clinical data Pregnancy cat …   Wikipedia Arylcyclohexylamine — Phencyclidine, the prototypal arylcyclohexylamine derivative. Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs. Contents …   Wikipedia Racemorphan — Systematic (IUPAC) name (±) 17 methylmorphinan 3 ol Clinical data Pregnancy cat.  ? …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”