Interleukin 1, beta, also known as IL1B, is a human gene. Interleukin-1 beta is a cytokine. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β.

section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [cite web | title = Entrez Gene: IL1B interleukin 1, beta| url =| accessdate = ]

ee also

* Interleukin 1


Further reading

citations =
*cite journal | author=Smirnova MG, Kiselev SL, Gnuchev NV, "et al." |title=Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. |journal=Eur. Cytokine Netw. |volume=13 |issue= 2 |pages= 161–72 |year= 2003 |pmid= 12101072 |doi=
*cite journal | author=Griffin WS, Mrak RE |title=Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. |journal=J. Leukoc. Biol. |volume=72 |issue= 2 |pages= 233–8 |year= 2002 |pmid= 12149413 |doi=
*cite journal | author=Arend WP |title=The balance between IL-1 and IL-1Ra in disease. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 323–40 |year= 2003 |pmid= 12220547 |doi=
*cite journal | author=Chakravorty M, Ghosh A, Choudhury A, "et al." |title=Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India. |journal=Hum. Biol. |volume=76 |issue= 1 |pages= 153–9 |year= 2004 |pmid= 15222686 |doi=
*cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=
*cite journal | author=Maruyama Y, Stenvinkel P, Lindholm B |title=Role of interleukin-1beta in the development of malnutrition in chronic renal failure patients. |journal=Blood Purif. |volume=23 |issue= 4 |pages= 275–81 |year= 2005 |pmid= 15925866 |doi= 10.1159/000086012
*cite journal | author=Roy D, Sarkar S, Felty Q |title=Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. |journal=Front. Biosci. |volume=11 |issue= |pages= 889–98 |year= 2006 |pmid= 16146780 |doi=
*cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=
*cite journal | author=Prinz C, Schwendy S, Voland P |title=H pylori and gastric cancer: shifting the global burden. |journal=World J. Gastroenterol. |volume=12 |issue= 34 |pages= 5458–64 |year= 2006 |pmid= 17006981 |doi=
*cite journal | author=Kamangar F, Cheng C, Abnet CC, Rabkin CS |title=Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 10 |pages= 1920–8 |year= 2007 |pmid= 17035400 |doi= 10.1158/1055-9965.EPI-06-0267

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • IL1B — …   Википедия

  • Интерлейкин 1, бета — Обозначения Символы IL1B; , IL1F2 Entrez Gene …   Википедия

  • Catechin — IUPAC name (2R,3S) 2 (3,4 dihydroxyphenyl) 3,4 dihydro 2H chromene 3,5,7 …   Wikipedia

  • Interleukin-1β — Vorhandene Strukturdaten: s. UniProt Masse/Länge …   Deutsch Wikipedia

  • Anthrax — For other uses, see Anthrax (disambiguation). Anthrax Classification and external resources Microphotograph of a Gram stain of the bacterium Bacillus anthracis, the cause of the anthrax disease …   Wikipedia

  • Haematopoiesis — Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Haematopoiesis (from Ancient Greek: αἷμα, blood ; ποιεῖν to make ) (or hematopoiesis in the United States; sometimes also haemopoiesis or… …   Wikipedia

  • Cytokine — Cytokines (Greek cyto , cell; and kinos, movement) are small cell signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used… …   Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • Interleukin 1 — protein Name = interleukin 1, alpha caption = Crystal structure of IL 1a (PDB|2ILA). width = 250 HGNCid = 5991 Symbol = IL1A AltSymbols = IL1; IL 1A; IL1; IL1 ALPHA; IL1F1 EntrezGene = 3552 OMIM = 147760 RefSeq = NM 000575 UniProt = P01583 PDB =… …   Wikipedia

  • Interleukin 6 — (interferon, beta 2) PDB rendering based on 1ALU …   Wikipedia