IL1B


IL1B

Interleukin 1, beta, also known as IL1B, is a human gene. Interleukin-1 beta is a cytokine. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [cite web | title = Entrez Gene: IL1B interleukin 1, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3553| accessdate = ]

ee also

* Interleukin 1

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Smirnova MG, Kiselev SL, Gnuchev NV, "et al." |title=Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion. |journal=Eur. Cytokine Netw. |volume=13 |issue= 2 |pages= 161–72 |year= 2003 |pmid= 12101072 |doi=
*cite journal | author=Griffin WS, Mrak RE |title=Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. |journal=J. Leukoc. Biol. |volume=72 |issue= 2 |pages= 233–8 |year= 2002 |pmid= 12149413 |doi=
*cite journal | author=Arend WP |title=The balance between IL-1 and IL-1Ra in disease. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 323–40 |year= 2003 |pmid= 12220547 |doi=
*cite journal | author=Chakravorty M, Ghosh A, Choudhury A, "et al." |title=Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India. |journal=Hum. Biol. |volume=76 |issue= 1 |pages= 153–9 |year= 2004 |pmid= 15222686 |doi=
*cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=
*cite journal | author=Maruyama Y, Stenvinkel P, Lindholm B |title=Role of interleukin-1beta in the development of malnutrition in chronic renal failure patients. |journal=Blood Purif. |volume=23 |issue= 4 |pages= 275–81 |year= 2005 |pmid= 15925866 |doi= 10.1159/000086012
*cite journal | author=Roy D, Sarkar S, Felty Q |title=Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. |journal=Front. Biosci. |volume=11 |issue= |pages= 889–98 |year= 2006 |pmid= 16146780 |doi=
*cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=
*cite journal | author=Prinz C, Schwendy S, Voland P |title=H pylori and gastric cancer: shifting the global burden. |journal=World J. Gastroenterol. |volume=12 |issue= 34 |pages= 5458–64 |year= 2006 |pmid= 17006981 |doi=
*cite journal | author=Kamangar F, Cheng C, Abnet CC, Rabkin CS |title=Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 10 |pages= 1920–8 |year= 2007 |pmid= 17035400 |doi= 10.1158/1055-9965.EPI-06-0267

External links

*

PBB_Controls
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