ImageFile1 = Adenine chemical structure.png ImageSize1 = 150px
ImageFileL2 = Adenine-3D-balls.png ImageSizeL2 = 100px
ImageFileR2 = Adenine-3D-vdW.png ImageSizeR2 = 100px
IUPACName = 9H-purin-6-amine
OtherNames = 6-aminopurine
Section1 = Chembox Identifiers
CASNo = 73-24-5
PubChem = 190
SMILES = Nc1ncnc2 [nH] cnc12
MeSHName =

Section2 = Chembox Properties
Formula = C5H5N5
MolarMass = 135.127 g/mol
Appearance =
Density =
MeltingPt = 360 - 365 °C
BoilingPt =
Adenosine triphosphate is a type of energy
Section3 = Chembox Hazards
Solubility =
MainHazards =
FlashPt =
Autoignition =

Adenine is a purine with a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), and protein synthesis, as a chemical component of DNA and RNA. [ [ Definition of Adenine from the Genetics Home Reference] - National Institutes of Health] the shape of adenine is complementary to either thymine or uracil.


It forms several tautomers, compounds that can be rapidly interconverted and are often considered equivalent.


The Purine metabolism involves the formation of Adenine and Guanine. Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is synthesised on a pre-existing ribose through a complex pathway using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as formate ions transferred from the coenzyme tetrahydrofolate.


Adenine is one of the two purine nucleobases (the other being guanine) used in forming nucleotides of the nucleic acids. In DNA, adenine binds to thymine via two hydrogen bonds to assist in stabilizing the nucleic acid structures. In RNA, which is used in the cytoplasm for protein synthesis, adenine binds to uracil.

Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose. It forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between chemical reactions.


In older literature, adenine was sometimes called Vitamin B4. [cite journal
journal=Biochem J.
title=The assay of vitamin B4
author=Vera Reader
] It is no longer considered a true vitamin or part of the Vitamin B complex. However, two B vitamins, niacin and riboflavin, bind with adenine to form the essential cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), respectively.

Some think that, at the origin of life on Earth, the first adenine was formed by the polymerization of five hydrogen cyanide (HCN) molecules.Fact|date=May 2008 However, this has been criticized by some chemists. [cite journal
title=The prebiotic role of adenine: A critical analysis
journal=Origins of Life and Evolution of Biospheres
date=June, 1995


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Look at other dictionaries:

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  • Adenine — Adenine, benannt nach der Nukleinbase Adenin, ist eine Skriptsprache, welche im Rahmen des Haystack und Oxygen Projekts vom MIT Computer Science And Artificial Intelligence Laboratory (CSAIL) in Zusammenarbeit mit NTT entwickelt wird. Ein… …   Deutsch Wikipedia

  • adénine — [ adenin ] n. f. • 1885 Adenin, en all.; du gr. adên « glande » et ine ♦ Biochim. Base azotée purique, l une des quatre bases essentielles des acides nucléiques. ● adénine nom féminin Base purique constitutive des acides nucléiques (A.D.N., A.R.N …   Encyclopédie Universelle

  • adenine — adenine. См. аденин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • adenine — (n.) crystaline base, 1885, coined by German physiologist/chemist Albrecht Kossel (1853 1927) from Gk. aden gland + chemical suffix INE (Cf. ine) (2). So called because it was derived from the pancreas of an ox …   Etymology dictionary

  • adenine — [ad′ə nēn΄, ad′ənin΄] n. [ ADEN(O) + INE3] a white, crystalline purine base, C5H5N5, contained in the DNA, RNA, and ADP of all tissue: it links with thymine in the DNA structure …   English World dictionary

  • Adenine (A) — One member of the A T (adenine thymine) base pair in DNA. The other base pair in DNA is G C (guanine cytosine). Each base pair forms a rung of the DNA ladder. A DNA nucleotide is made of a molecule of sugar, a molecule of phosphoric acid, and a… …   Medical dictionary

  • adenine — /ad n in, een , uyn /, n. Biochem. a purine base, C5H5N5, one of the fundamental components of nucleic acids, as DNA, in which it forms a base pair with thymine, and RNA, in which it pairs with uracil. Symbol: A [1880 85; < G Adenin; see ADEN ,… …   Universalium

  • adenine — One of the two major purines (the other being guanine) found in both RNA and DNA, and also in various free nucleotides of importance to the body, such as AMP (adenylic acid), ATP, NAD+ and NADP+, and FAD; in all these smaller compounds, a. is… …   Medical dictionary