Acid phosphatase


Acid phosphatase

Acid phosphatase is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. It is basically a phosphomonoesterase. It is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, it has an acid pH optimum.

Different forms of acid phosphatase are found in different organs, and their serum levels are used as a diagnostic for disease in the corresponding organs. For example, elevated prostatic acid phosphatase levels may indicate the presence of prostate cancer.

Acid phosphatase catalyzes the following reaction at an optimal pH below 7:

Orthophosphoric monoester + H2O → alcohol + H3PO4

Phosphatase enzymes are also used by soil microorganisms to access organically bound phosphate nutrients. An assay on the rates of activity of these enzymes may be used to ascertain biological demand for phosphates in the soil.

ee also

*alkaline phosphatase

External links

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  • Acid phosphatase — is an enzyme that works under acid conditions and is made in the liver, spleen, bone marrow and the prostate gland. Abnormally high serum levels of the enzyme may, for example, indicate prostate disease (infection, injury, or cancer). * * * acid… …   Medical dictionary

  • acid phosphatase — acid phosphatase. См. кислая фосфатаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • acid phosphatase — noun Date: 1949 a phosphatase (as the phosphomonoesterase from the prostate gland) optimally active in acid medium …   New Collegiate Dictionary

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  • Prostate acid phosphatase — An enzyme produced by the prostate that is elevated in some patients with prostate cancer …   Medical dictionary