Diosmin

Diosmin

Systematic (IUPAC) name
5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy -6-[[(2R,3R,4R,5R,6S) -3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	520-27-4 N
ATC code	C05CA03
PubChem	CID 5281613
ChemSpider	4444932 Y
UNII	7QM776WJ5N Y
KEGG	D07858 Y
ChEMBL	CHEMBL231884 Y
Chemical data
Formula	C28H32O15
Mol. mass	608.545 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1 Y Key:GZSOSUNBTXMUFQ-YFAPSIMESA-N Y
N(what is this?)  (verify)

Diosmin is a semisynthetic phlebotropic drug (modified hesperidin), a member of the flavonoid family. It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin.^{[citation needed]}

Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published.^[1][2]

Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States and the rest of Europe.

Diosmin aglycone is diosmetin.

Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats.^[3] It is also speculated that diosmin might have potential in the treatment of neurodegenerative diseases, such as alzheimer's disease, and its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells, in vitro.^[4]

Mechanisms

Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.

Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries. Furthermore, diosmin with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.

At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.

Diosmin reduces the expression of endothelial adhesion molecules (ICAM1, VCAM1), and inhibits the adhesion, migration, and activation of leukocytes at the capillary level. This leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins (PGE2, PGF2a).

Regulatory status

Diosmin is distributed in the U.S. as a dietary supplement.^[5] The FDA concluded that there was inadequate evidence on which to base an expectation of safety.^[6] One company that markets diosmin supplements, Nutratech, has responded that diosmin can reasonably be expected to be safe on the basis of clinical trials, and has a long history of use in Europe. In the U.S., dietary supplements are regulated under Dietary Supplement Health and Education Act of 1994, which does not require proof of efficacy so long as no specific health claims are made.

See also

• Daflon

References

1. ^ Veverková L, Kalac J, Jedlicka V, Wechsler J (August 2005). "[Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping]" (in Czech). Rozhl Chir 84 (8): 410–2, 414–6. PMID 16218350. 
2. ^ Danielsson G, Jungbeck C, Peterson K, Norgren L (January 2002). "A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease". Eur J Vasc Endovasc Surg 23 (1): 73–6. doi:10.1053/ejvs.2001.1531. PMID 11748952. http://linkinghub.elsevier.com/retrieve/pii/S107858840191531X. 
3. ^ Leelavinothan Pari, Subramani Srinivasan, Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats, Biomedicine & Pharmacotherapy, Volume 64, Issue 7, September 2010, Pages 477-481.
4. ^ Sanjay L.Dholakiya, Kenza E. Benzeroual, Protective effect of Diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF- [alpha] expression, Toxicology in Vitro, In Press, Accepted Manuscript, Available online 6 April 2011.
5. ^ Public Health Service memorandum, Sept. 13, 2005
6. ^ New Dietary Ingredients in Dietary Supplements, U. S. Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Nutritional Products, Labeling, and Dietary Supplements February 2001 (Updated September 10, 2001) [1], Memorandum [2]

External links

• Diosmin, Alternative Medicine Review, Sept 2004