N-acetyltransferase

N-acetyltransferase

N-acetyltransferase is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines.[1] They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.

Examples

The following is a list of human genes that encode N-acetyltransferase enzymes:

Symbol Name
AANAT arylalkylamine N-acetyltransferase
ARD1A ARD1 homolog A, N-acetyltransferase (S. cerevisiae)
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
MAK10 MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NAT5 N-acetyltransferase 5 (GCN5-related, putative)
NAT6 N-acetyltransferase 6 (GCN5-related)
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NAT8L N-acetyltransferase 8-like (GCN5-related, putative)
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NAT10 N-acetyltransferase 10 (GCN5-related)
NAT11 N-acetyltransferase 11 (GCN5-related, putative)
NAT12 N-acetyltransferase 12 (GCN5-related, putative)
NAT13 N-acetyltransferase 13 (GCN5-related)
NAT14 N-acetyltransferase 14 (GCN5-related, putative)
NAT15 N-acetyltransferase 15 (GCN5-related, putative)

References

  1. ^ Evans DA (1989). "N-acetyltransferase". Pharmacology & Therapeutics 42 (2): 157–234. doi:10.1016/0163-7258(89)90036-3. PMID 2664821. 

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