- Wolffian duct
Name = PAGENAME
Latin = d. mesonephricus, d. Wolffi
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GrayPage = 1205
Urogenital sinusof female human embryoof eight and a half to nine weeks old.
Caption2 = Transverse section of a chick embryo of forty-five hours’ incubation.
Days = 28
CarnegieStage = 11
DorlandsPre = d_29
DorlandsSuf = 12314957
The Wolffian duct (also known as archinephric duct, Leydig's duct, mesonephric duct, or nephric duct) is a paired organ found in mammals including
humans during embryogenesis.
It connects the primitive kidney
Wolffian body(or " mesonephros") to the cloacaand serves as the anlagefor certain male reproductive organs.
In both the male and the female the Wolffian duct develops in to the
trigone of urinary bladder, a part of the bladder wall. However, further development differentiates between the sexes in the development of the urinary and reproductive organs.
male, it develops into a system of connected organs between the testisand the prostate, namely the rete testis, the efferent ducts, the epididymis, the vas deferens, the seminal vesicle, and the prostate.
For this it is critical that the ducts are exposed to
testosteroneduring embryogenesis. Testosteronebinds to and activates androgen receptor, affecting intracellular signals and modifying the expression of numerous genes.cite journal |author=Hannema SE, Print CG, Charnock-Jones DS, Coleman N, Hughes IA |title=Changes in gene expression during Wolffian duct development |journal=Horm. Res. |volume=65 |issue=4 |pages=200–9 |year=2006 |pmid=16567946 |doi=10.1159/000092408]
In the mature male, the function of this system is to store and mature sperm, and provide accessory
female, in the absence of testosterone support, the Wolffian ducts regresses, and inclusions may persist. The epoophoronand Skene's glandsmay be present. Also, lateral to the wall of the vagina a Gartner's ductor cyst could develop as a remnant.
It is named after
Caspar Friedrich Wolffwho described the mesonephrosand its ducts in his dissertationin 1759. [WhoNamedIt|synd|2845]
List of homologues of the human reproductive system
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