Nedocromil Systematic (IUPAC) name 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid Clinical data Trade names Alocril AHFS/Drugs.com MedlinePlus Pregnancy cat. ? Legal status POM (UK) ℞-only (US) Routes Inhalation and eye drops Pharmacokinetic data Protein binding 89% Metabolism not metabolized Half-life ~3.3 hours Excretion excreted unchanged Identifiers CAS number ATC code R01 R03, S01 PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Chemical data Formula C19H17NO7 Mol. mass 371.341 g/mol SMILES & (what is this?)
Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well known inhaler medications) and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.
Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.
- ^ "Nedocromil eye drops" (in English). 2007-02-02. http://www.patient.co.uk/showdoc/30003772. Retrieved 2009-08-04.
- ^ http://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/ucm089433.pdf
Decongestants and other nasal preparations (R01) TopicalSympathomimetics, plainAntiallergic agents,
excluding corticosteroidsOther nasal preparations
Drugs for obstructive airway diseases: asthma/COPD (R03) Adrenergics, inhalantsLong acting β2-agonists (LABA)other Glucocorticoids Anticholinergics/
Mast cell stabilizersCromoglicate • Nedocromil Xanthines Eicosanoid inhibitionThromboxane receptor antagonists Combination products This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.