Martin Karplus


Martin Karplus

Martin Karplus (born March 15, 1930, Vienna) is an Austrian-born American theoretical chemist. He has been Theodore William Richards Professor of Chemistry at Harvard University since 1979. He is also Director of the Biophysical Chemistry Laboratory, a joint laboratory of CNRS and Universite de Strasbourg in Strasbourg, France.

He received a BA degree from Harvard University in 1950, and a Ph.D. from California Institute of Technology in 1953 while working with Linus Pauling. He was an NSF Postdoctoral Fellow at Oxford University (1953–55) where he worked with Charles Coulson. His brother, Robert Karplus, was an internationally recognised physicist and educator at University of California, Berkeley.

Contents

Contributions

Martin Karplus has made significant contributions to many fields in physical chemistry, including the nuclear magnetic resonance spectroscopy, chemical dynamics, quantum chemistry, and most notably, the molecular dynamics simulations of biological macromolecules.

Karplus has made varied contributions to nuclear magnetic resonance spectroscopy, particularly to the understanding of nuclear spin-spin coupling and electron spin resonance spectroscopy. The Karplus equation describing the correlation between coupling constants and dihedral angles in protein nuclear magnetic resonance spectroscopy is named after him.

With Andrew McCammon and Bruce Gelin, he published the first molecular dynamics simulation of a protein, the Bovine Pancreatic Trypsin Inhibitor BPTI.[1]

Current research

His current research is concerned primarily with the properties of molecules of biological interest. His group originated and currently coordinates the development of the CHARMM program for molecular dynamics simulations. He is a member of the International Academy of Quantum Molecular Science. He has supervised over 200 graduate students and postdoctoral researchers in his long career (since 1955) in the University of Illinois, Columbia University, and Harvard University.

Notable students

See also

References

  1. ^ McCammon, J. A.; Gelin, B. R.; Karplus, M. (1977). "Dynamics of folded proteins". Nature 267 (5612): 585–590. doi:10.1038/267585a0. PMID 301613.  edit

External links


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Martin Karplus — (né le 15 mars 1930 à Vienne en Autriche) est un chimiste théoricien américain. Il est professeur a l’université Harvard depuis 1979 et directeur du Laboratoire de Chimie Biophysique un laboratoire commun du CNRS et de l’université de Strasbourg …   Wikipédia en Français

  • Martin Karplus — (* 15. März 1930 in Wien) ist ein in Österreich geborener US amerikanischer theoretischer Chemiker. Er erwarb den Grad B.A. an der Harvard University im Jahr 1950 und wurde 1953 zum Ph. D. am California Institute of Technology mit Arbeiten in der …   Deutsch Wikipedia

  • Karplus — ist der Familienname folgender Personen: Arnold Karplus (1877–1968), österreichischer Architekt Johann Paul Karplus (1866–1966), österreichischer Neurophysiologe und Psychiater Kevin Karplus, US amerikanischer Bioinformatiker Martin Karplus (*… …   Deutsch Wikipedia

  • Karplus-Beziehung — Das Diagramm einer typischen Karplus Beziehung Die Karplus Beziehung ist eine Gleichung, die nach ihrem Entdecker Martin Karplus benannt wurde, welche eine Korrelation der 3J Kopplungskonstante und dem Diederwinkel in der NMR Spektroskopie… …   Deutsch Wikipedia

  • Karplus equation — The Karplus equation, named after Martin Karplus, describes the correlation between 3J coupling constants and dihedral torsion angles in nuclear magnetic resonance spectroscopy::J(phi) = A cos^2 phi + B cos,phi + Cwhere J is the 3 J coupling… …   Wikipedia

  • Martin Deutsch — (* 15. Januar 1917 in Wien; † 16. August 2002 in Cambridge (Massachusetts)) war ein US amerikanischer Experimentalphysiker. Er entdeckte das Positronium. Leben Deutsch wurde als Sohn eines jüdischen Ärzteehepaares (Felix und Helene Deutsch)… …   Deutsch Wikipedia

  • Robert Karplus — (February 23, 1927 March 22, 1990) was a theoretical physicist and leader in the field of science education.Early lifeRobert Karplus was born in Vienna, where he lived until the German occupation of Austria in 1938. He emigrated with his mother… …   Wikipedia

  • Robert Karplus — (* 23. Februar 1927 in Wien; † 22. März 1990) war ein US amerikanischer theoretischer Physiker und Physik Pädagoge. Inhaltsverzeichnis 1 Leben und Werk 2 Schriften 3 Literatur …   Deutsch Wikipedia

  • Jean-Louis Martin (sciences) — Jean Louis Martin (né en 1952) est un biologiste français. Après l obtention du diplôme d ingénieur de l ENSEA en 1975, Jean Louis Martin obtient un DEA en physiologie cardio circulatoire (1976, Paris XI) et un DERBH en biologie humaine… …   Wikipédia en Français

  • Jean-louis martin (sciences) — Jean Louis Martin (né en 1952) biologiste français Après l obtention du diplôme d ingénieur de l ENSEA en 1975, Jean Louis Martin obtient un DEA en Physiologie cardio circulatoire (1976, Paris XI) et un DERBH en Biologie humaine (1977,… …   Wikipédia en Français