- Local gigantism
s, where it is termed macrodactyly. However, sometimes an entire limb may be enlarged.
Local gigantism may be caused by a heterogeneous group of both congenital and acquired conditions.
Congenital causes include:
Klippel Trenaunay Weber syndrome
macrodystrophia lipomatosa[ [http://www.ijri.org/articles/archives/20001002/letter3.htm Letter to the Indian Journal of Radiology and Imaging] ]
neurofibromatosis, [cite journal |author=Lassmann H, Gebhart W, Mamoli B, Niebauer G |title=Nervous lesions in a case of local gigantism |journal=Acta Neuropathol. |volume=38 |issue=2 |pages=109–15 |year=1977 |pmid=878849 |doi=] [cite journal |author=Chung IH, Kim NH, Choi IY |title=Macrodactylism associated with neurofibroma of the median nerve. A case report |journal=Yonsei Med. J. |volume=14 |issue= |pages=49–52 |year=1973 |pmid=4804132 |doi=]
lipoatrophic diabetes. [ [http://www.ijri.org/articles/current_issue/gyn_349.asp Some case reports] ]
Proteus syndrome, which affected the Elephant Man
There are a number of acquired causes of local gigantism. A body part can attain bigger size from causes as common as the following:
inflammation, due to trauma or infection
tumors like osteoid osteoma, melorheostosis, and lipofibromatous hamartoma[cite journal |author=Razzaghi A, Anastakis DJ |title=Lipofibromatous hamartoma: review of early diagnosis and treatment |journal=Canadian Journal of Surgery. Journal canadien de chirurgie |volume=48 |issue=5 |pages=394–9 |year=2005 |pmid=16248139 |doi=]
Arteriovenous malformations occurring on a limb, before the closure of epiphysesin long bones [ [http://indianheartjournal.com/SeptOctober2001/abstact/659-662/265_focal_gigantism.htm Case report] ]
Elephantiasis, which is quite common in south-east asiadue to prevalence of filariasis.
As the causes of local gigantism are varied, treatment depends on the particular condition. Treatment may range from
antibioticsand other medical therapy, to surgeryin order to correct the anatomical anomaly.
* [http://www.medcyclopaedia.com/library/topics/volume_iii_1/g/GIGANTISM.aspx Medcyclopedia article]
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