- Ghon's complex
Ghon's complex, sometimes called Ranke's complex is a lesion seen in the lung that is caused by
tuberculosis. The two alternative names come from the scientists Karl Ernst Ranke, or Anton Ghon, respectively. [ [http://www.whonamedit.com/synd.cfm/3647.html Ghon's primary lesion] Whonamedit.com, Accessed 21 January 2008] [cite journal |author=Ober WB |title=Ghon but not forgotten: Anton Ghon and his complex |journal=Pathol Annu |volume=18 Pt 2 |issue= |pages=79–85 |year=1983 |pmid=6371678] The lesions consist of a calcified focus of infection and an associated lymph node. These lesions are particularly common in children and can retain viable bacteria, so are sources of long-term infection and may be involved in reactivation of the disease in later life. [cite journal |author=Curvo-Semedo L, Teixeira L, Caseiro-Alves F |title=Tuberculosis of the chest |journal=Eur J Radiol |volume=55 |issue=2 |pages=158–72 |year=2005 |pmid=15905057 |doi=10.1016/j.ejrad.2005.04.014]
Specifically, the Ghon's complex is a combination of the "Ghon's focus" (area of initial infection by airborne bacillus) and a
lymphaticlesion. Approximately two to three weeks after the Ghon's focus has developed, the area undergoes " caseous necrosis" (cheeselike). Free tubercle bacilli, or bacilli within macrophages drain out from the area towards the affected lungs' lymph nodes. It is in this location, at the lymph nodes, that the bacilli will form caseous granulomas. This, in combination with the initial area of infection, will make up the Ghon's complex. Typically these areas heal with calcification visible on chest X-ray, with the two causes virtually indistinguishable.
Ghon focusGross appearance there is a small tan-yellow subpleural granuloma in the mid-lung field on the right. In the hilum is a small yellow tan granuloma in a hilar lymph node next to a bronchus
*Porth, Carol Mattson. Pathophysiology: Concepts of Altered Health States, 7th edition. Philadelphia: Lippincott Williams & Wilkins, 2005.
Wikimedia Foundation. 2010.
Look at other dictionaries:
Ghon focus — A Ghon focus is a primary lesion caused by mycobacterium bacilli (tuberculosis) developed in the lung of a previously uninfected individual. It is named for Anton Ghon (1866 1936), an Austrian pathologist.It is a small area of granulomatous… … Wikipedia
complex — 1. An organized constellation of feelings, thoughts, perceptions, and memories that may be in part unconscious and may strongly influence associations and attitudes. 2. In chemistry, the relatively stable combination of two or more compounds into … Medical dictionary
Ghon focus — the primary parenchymal lesion of primary pulmonary tuberculosis; when associated with a corresponding lymph node focus, it is known as the primary or Ghon complex. Called also Ghon primary lesion and Ghon tubercle. Ghon focus (arrow) in… … Medical dictionary
Ghon complex focus (primary lesion tubercle) — (gon) [Anton Ghon, Austrian born pathologist in Czechoslovakia, 1866â€“1936] see primary complex, and see under focus … Medical dictionary
Ghon — Anton, Czechoslovakian pathologist, 1866–1936. See G. complex, G. focus, G. primary lesion, G. tubercle … Medical dictionary
Ghon complex — (gon) The initial focus of parenchymal infection in primary pulmonary tuberculosis … Dictionary of microbiology
Ghon complex — primary c. (def. 1) … Medical dictionary
Anton Ghon — (January 1, 1866 April 23, 1936) was an Austrian pathologist who was a native of Villach. In 1890 he earned his medical degree in Graz, and afterwards spent several years at the pathological institute in Vienna, where he worked with Anton… … Wikipedia
Mycobacterium avium complex — (MAC) is a group of genetically related bacteria belonging to the genus Mycobacterium. It includes Mycobacterium avium and Mycobacterium intracellulare. Some sources also include Mycobacterium avium subspecies paratuberculosis (MAP) … Wikipedia
Complejo de Ghon — En medicina, el complejo de Ghon, a veces llamado complejo de Accinelli es una lesión pulmonar causada en la tuberculosis que consiste en un foco de calcificación conjuntamente con una infección de ganglios linfáticos. Estas lesiones son… … Wikipedia Español