5-Lipoxygenase activating protein


5-Lipoxygenase activating protein

protein
Name=arachidonate 5-lipoxygenase-activating protein
caption=


width=
HGNCid=436
Symbol=ALOX5AP
AltSymbols=
EntrezGene=241
OMIM=603700
RefSeq=NM_001629
UniProt=P20292
PDB=
ECnumber=
Chromosome=13
Arm=q
Band=12
LocusSupplementaryData=

5-Lipoxygenase activating protein, or FLAP, is an enzyme necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes.cite journal |author= Peters-Golden M, Brock TG |title=5-lipoxygenase and FLAP|journal= Prostaglandins Leukot Essent Fatty Acids |volume=69 |issue=2-3 |pages=99–109 |year= 2003 | pmid = 12895592 |doi=10.1016/S0952-3278(03)00070-X] It is bound to the nuclear membrane.

Pathology

Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease.cite journal |author=Manev H, Manev R |title=5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease|journal= Med Hypotheses |volume=66 |issue=3 |pages=501–3 |year= 2006 | pmid = 16278051 |doi=10.1016/j.mehy.2005.09.031]

References

External links

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