Ceragenix Pharmaceuticals


Ceragenix Pharmaceuticals
Logo

Ceragenix Pharmaceuticals, Inc. (OTCBB: CGXP) is a biopharmaceutical company that discovers, develops and commercializes anti-infective drugs based on its proprietary class of compounds, Ceragenins. Active against a broad range of gram positive and gram negative bacteria, these agents are being developed as anti-infective medical device coatings and as therapeutics for serious antibiotic-resistant organisms.

Ceragenix Pharmaceuticals Inc. is an emerging biopharmaceutical company headquartered in Denver, Colorado. It develops prescription therapies based on a platform of proprietary surface active technologies—skin Barrier Repair Technology (BRT) and Cerageninis, a new class of broad spectrum anti-infectives.

Ceragenix developed EpiCeram. It is a topical non-steroidal skin care cream based on the research of Peter Elias for the treatment of atopic dermatitis (eczema).

Ceragenix's second platform technology addresses the growing threat of multidrug resistant bacterial and viral infections. The Ceragenin anti-infective technology is based on the research of Dr. Paul B. Savage, Professor and Associate Chair of Departments of Chemistry and Biochemistry at Brigham Young University (BYU, Provo, Utah). These compounds are aminosterols that mimic the activity of the naturally occurring antimicrobial peptides which form part of the human body's innate immune system and early line of defense against bacterial, viruses, fungi and even certain cancers. The Ceragenins have been the subject of extensive in vitro analysis and have demonstrated a broad range of action against clinically relevant organisms such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), tobramycin-resistant Pseudomonas aeruginosa (PATR), Escherichia coli, vaccinia virus, HIV, and Bacillus anthracis (anthrax) among others. The compounds work by tearing apart the outer membranes of their targets. The compounds are positively charged and are electrostatically attracted to the negatively-charged phospholipids that tend to distinguish prokaryotic from eukaryotic cells. Ceragenix is currently working on developing a wound dressing for medical device insertion points to help reduce the incidence of hospital acquired infections which claim over 50,000 lives each year in the United States.[citation needed]

External links


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Barr Pharmaceuticals — Inc Industry Pharmaceuticals Medical Devices Founded New York (1970) Headquarters Montvale, NJ, USA …   Wikipedia

  • Vion Pharmaceuticals, Inc. — Vion Pharmaceuticals, Inc. Former type Public OTC BB: VIONQ.OB) Industry Pharmaceuticals Founded 1992 …   Wikipedia

  • Bradley Pharmaceuticals — Bradley Pharmaceuticals, Inc. Type Merged Industry Pharmaceuticals Successor Nycomed …   Wikipedia

  • OSI Pharmaceuticals — OSI Pharmaceuticals, Inc. Type Subsidiary Industry Biopharmaceuticals Biotherapeutics[1] …   Wikipedia

  • Nereus Pharmaceuticals — is a pharmaceutical company focused on the development of natural products from marine microbial sources into small molecule human therapeutics.[1] The major disease area addressed by Nereus is cancer. As of 2008, Nereus has no marketed products… …   Wikipedia

  • Cortex Pharmaceuticals — (OTCBB: CORX) is a pharmaceutical company based in Irvine, California specializing in positive allosteric modulators of the AMPA receptor known as Ampakines. History February 2005 – Cortex received U.S. Food and Drug Administration approval to… …   Wikipedia

  • Norwich Pharmaceuticals — Logo Norwich Pharmaceuticals is a manufacturer, packager and distributor of prescription drugs and over the counter products. Laboratory support services include stability evaluation, microbiological testing, analytical testing and method… …   Wikipedia

  • Ovation Pharmaceuticals — Ovation Pharmaceuticals, founded in 2000 by Jeffrey Aronin and Dr. Joel E. Bernstein, is a manufacturer of pharmaceuticals products including the popular selling ADHD medicine Desoxyn, brand name for methamphetamine hydrochloride, and Vigabatrin… …   Wikipedia

  • Century Pharmaceuticals — Century Pharmaceuticals, Inc. manufactures Dakin s Solution, for the treatment of chronic wounds. Dakin s is a topical, broad spectrum antimicrobial, effective against MRSA, Vancomycin resistant enterococcus, and other antibiotic resistant… …   Wikipedia

  • Ceragenin — Ceragenins, or cationic steroid antibiotics (CSAs), are synthetically produced small molecule chemical compounds consisting of a sterol backbone with amino acids and other chemical groups attached to them. These compounds have a net positive… …   Wikipedia