Trimethadione

Trimethadione
Trimethadione
Systematic (IUPAC) name
3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
Clinical data
Trade names Tridione
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. X
Legal status Prescription only
Routes  ?
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half-life  ?
Excretion  ?
Identifiers
CAS number 127-48-0 YesY
ATC code N03AC02
PubChem CID 5576
DrugBank APRD00315
ChemSpider 5374 YesY
UNII R7GV3H6FQ4 N
KEGG D00392 YesY
ChEMBL CHEMBL695 YesY
Chemical data
Formula C6H9NO3 
Mol. mass 143.141 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

Contents

Fetal trimethadione syndrome

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth retardation (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.[1]

Chemistry

Trimethadione, 3,5,5-trimethyloxazolidine-2,4-dione, may be synthesized by methylating 5,5-trimethyloxazolidine-2,4-dione with dimethylsulfate. Starting 5,5-trimethyloxazolidine-2,4-dione is in turn synthesized by the cyclocondensation of the ester of 2-hydroxyisobutyric acid with urea.

Trimethadione synthesis.png

References

External links


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См. также в других словарях:

  • trimethadione — [trī meth΄ə dī′ōn] n. [trimeth(yl) (< TRI + METHYL) + a + DI 1 + ONE] a white, crystalline material, C6H9NO3, used in treating epilepsy …   English World dictionary

  • trimethadione — /truy meth euh duy ohn/, n. Pharm. a synthetic, white, crystalline powder, C6H9NO3, used as an anticonvulsant to control petit mal epileptic seizures. [trimeth(yl) + (ox)a(zolidine)dione, components of its chemical name] * * * …   Universalium

  • trimethadione — noun An anticonvulsant drug used to control epilepsy …   Wiktionary

  • trimethadione — An obsolescent anticonvulsant used for the treatment of absence seizures (petit mal) and psychomotor epilepsy. SYN: troxidone. * * * tri·metha·di·one .trī .meth ə dī .ōn n a crystalline anticonvulsant C6H9NO3 used chiefly in the treatment of… …   Medical dictionary

  • trimethadione — tri·metha·di·one …   English syllables

  • trimethadione — (|)trī|methə|dīˌōn noun ( s) Etymology: trimethyl + connective a + dione : a crystalline anticonvulsant C6H9NO3 used chiefly in the treatment of petit mal epilepsy; 3,5,5 trimethyl 2,4 oxazolidine dione * * * /truy meth euh duy ohn/, n. Pharm. a… …   Useful english dictionary

  • Fetal trimethadione syndrome — (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others [Additional names include trimethadione embryopathy and trimethadione syndrome .] ) is a set of birth defects caused by the administration of the… …   Wikipedia

  • Oxazolidinedione — 2,4 Oxazolidenedione IUPAC name 1,3 Oxazolidine 2,4 dione …   Wikipedia

  • Anti-convulsivant — Antiépileptique Les antiépileptiques, anticonvulsants ou anticomitiaux, appartiennent à un groupe varié de médicaments utilisés dans la prévention ou l occurrence de l épilepsie. Leur action est symptomatique et non pas curative (ils sont… …   Wikipédia en Français

  • Anti-épileptique — Antiépileptique Les antiépileptiques, anticonvulsants ou anticomitiaux, appartiennent à un groupe varié de médicaments utilisés dans la prévention ou l occurrence de l épilepsie. Leur action est symptomatique et non pas curative (ils sont… …   Wikipédia en Français


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