type = combo
component1 = Ampicillin
class1 = Moderate-spectrum penicillin
component2 = Flucloxacillin
class2 = Antistaphylococcal penicillin
CAS_number =
ATC_prefix = J01
ATC_suffix = CR50
PubChem =
DrugBank =
pregnancy_AU =
pregnancy_US =
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Oral, intravenous

Co-fluampicil is the British Approved Name, for the combination of ampicillin and flucloxacillin β-lactam antibiotics (trade name Magnapen).


Ampicillin is a moderate spectrum penicillin antibiotic with good cover against Group A streptococcal infection whilst Flucloxacillin is a narrow spectrum antibiotic with cover against Staphylococcus aureus. The combination covers the two most likely bacteria in cellulitis infections in the arm or leg.


As Co-fluampicil 250/250 capsules containing 250mg of each component, Co-fluampicil 125/125 syrup or as Co-fluampicil 250/250 powder for reconstruction for intravenous injection.


Typical oral dosage is Co-fluampicil 250/250 four times a day, doubled in severe infection and half the dose for children under 10 years.


As per the individual components with stomach or bowel upset from the Flucloxacillin being the most common. Both parts are members of the penicillin family of antibiotics, and therefore should not be taken by patients allergic to penicillin. See Flucloxacillin for additional contraindications.


*British National Formulary '50' September 2005

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