Influenza Genome Sequencing Project

Influenza Genome Sequencing Project

The Influenza Genome Sequencing Project (IGSP) is an effort to dramatically improve the availability of genomic sequences and related information about the influenza (flu) viruses. The IGSP was started by Lone Simonsen (Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases), David Lipman and Steven Salzberg in early 2004, when they wrote a proposal to begin sequencing large numbers of influenza viruses at The Institute for Genomic Research (TIGR). The proposal was approved by the National Institutes of Health (NIH) and new technology development began that year, led by Elodie Ghedin at TIGR. Prior to this project, only a handful of flu genomes were publicly available. The project completed its first genomes in March 2005 and has rapidly accelerated since, with over 1800 genomes now in the public domain.

The project is funded by the National Institute of Allergy and Infectious Diseases (NIAID) which is a component of the NIH, which is an agency of the United States Department of Health and Human Services.

The sequencing effort, thus far conducted entirely at the NIAID Microbial Sequencing Center at TIGR, is revealing complete genetic blueprints of thousands of known human and avian influenza viruses. TIGR and NIAID are rapidly making all sequence information publicly available through GenBank, an international, searchable online database funded by NIH.

By putting critical genome knowledge in the public domain, project leaders hope to provide researchers with the information needed to develop new vaccines, therapies and diagnostics, and improve understanding of the overall molecular evolution of influenza and other genetic factors that determine their virulence. Such knowledge could not only help mitigate the impact of annual influenza epidemics, but could also improve scientific knowledge of the emergence of pandemic flu viruses.

The TIGR/NIAID IGSP has expanded to include a growing list of collaborators, who have contributed both expertise and valuable collections of influenza isolates. Key early contributors included Peter Palese of Mt. Sinai School of Medicine in New York, Jill Taylor of the Wadsworth Center at the New York State Department of Health, Lance Jennings of Canterbury Health Laboratories (New Zealand), Jeff Taubenberger of the Armed Forces Institute of Pathology (who later moved to NIH), Richard Slemons of Ohio State University and Rob Webster of St. Jude's Children's Hospital in Memphis, Tennessee. In 2006 the project was joined by Ilaria Capua of the Istituto Zooprofilattico Sperimentale delle Venezie (in Italy), who contributed a valuable collection of avian flu isolates (including multiple H5N1 strains). Nancy Cox from the Centers for Disease Control and Prevention (CDC) and Robert Couch from Baylor College of Medicine also joined the project in 2006, contributing over 150 influenza B isolates. The project will begin prospective studies of the 2007 influenza season with collaborators Florence Bourgeois and Kenneth Mandl of Children's Hospital Boston and the Harvard School of Public Health and Laurel Edelman of Surveillance Data Inc.

As of January 2007, 1813 isolates had been completely sequenced from influenza viruses that are endemic in human ("human flu") avian ("bird flu") and swine ("swine flu") populations, including many strains of H3N2 (human), H1N1 (human), and H5N1 (avian). [ [ Nature] ]

Further reading

* [ Nature presents the initial results of this project]
* [ Free copy of Nature paper at senior author's home page]
* [ National Health Museum's on-line science news page summarizes the findings presented in Nature on the initial results of this project.]


* [ Influenza Sequencing Project home page at TIGR]
* [ Influenza Genome Sequencing Project home page at NIAID]
* [ Influenza virus resource at NCBI (NIH)]
* [ CDC]

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Influenza research — involves investigating molecular virology, pathogenesis, host immune responses, genomics, and epidemiology regarding influenza. The main goal of research is to develop influenza countermeasures such as vaccines, therapies and diagnostic tools.The …   Wikipedia

  • Influenza — Flu redirects here. For other uses, see Flu (disambiguation). This article is about the disease influenza. For the family of viruses that cause the disease, see Orthomyxoviridae. Influenza Classification …   Wikipedia

  • Influenza pandemic — Note: For information about the content, tone and sourcing of this article, please see the tags at the bottom of this page. An influenza pandemic is an epidemic of an influenza virus that spreads on a worldwide scale and infects a large… …   Wikipedia

  • Influenza vaccine — A vaccine is an inoculation designed to increase immunity against a specific disease. The influenza vaccine is an annual vaccine to protect against the highly variable influenza virus. Purpose and benefits of annual flu vaccination Influenza… …   Wikipedia

  • Influenza A virus subtype H3N2 — H3N2 is a subtype of the influenza A virus. Its name derives from the forms of the two kinds of proteins on the surface of its coat, hemagglutinin (H) and neuraminidase (N). H3N2 viruses can infect birds and mammals. In birds, humans and pigs the …   Wikipedia

  • Avian influenza — Influenza (Flu) …   Wikipedia

  • H5N1 genetic structure — is the molecular structure of the H5N1 virus s RNA.H5N1 is an Influenza A virus subtype. Experts believe it might mutate into a form that transmits easily from person to person. If such a mutation occurs, it might remain an H5N1 subtype or could… …   Wikipedia

  • Gripe — Este artículo trata sobre la enfermedad. Para la propagación mundial de 2009 2010 por H1N1, véase Pandemia de gripe A (H1N1) de 2009 2010. Gripe …   Wikipedia Español

  • Steven Salzberg — is an American Biologist and Computer Scientist who since 2005 has been the Director of the Center for Bioinformatics and Computational Biology at the University of Maryland, College Park, where he is also the Horvitz Professor of Computer… …   Wikipedia

  • National Institutes of Health — NIH redirects here. For other uses, see NIH (disambiguation). Coordinates: 39°00′02″N 77°06′09″W / 39.000443°N 77.102394°W / 39 …   Wikipedia