- Male-limited precocious puberty
Male-limited precocious puberty Classification and external resources OMIM 176410
Male-limited precocious puberty (also known as familial sexual precocity and gonadotropin-independent testotoxicosis) is a form of gonadotropin-independent precocious puberty in which boys experience early onset and progression of puberty. Signs of puberty can develop as early as an age of 1 year.
The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant condition with a mutation of the LH receptor. Treatment is with drugs that suppress gonadal steroidogenesis, such as cyproterone acetate, ketoconazole or spironolactone and testolactone.
- ^ a b Online 'Mendelian Inheritance in Man' (OMIM) 176410
- ^ Traggiai C, Stanhope R (2003). "Disorders of pubertal development". Best Pract Res Clin Obstet Gynaecol 17 (1): 41–56. doi:10.1053/ybeog.2003.0360. PMID 12758225.
- ^ Reiter EO, Norjavaara E (2005). "Testotoxicosis: current viewpoint". Pediatr Endocrinol Rev 3 (2): 77–86. PMID 16361981.
Endocrine pathology: endocrine diseases (E00–E35, 240–259) Pancreas/
pituitary axesHypothalamusPituitaryThyroidEndemic goitre · Toxic nodular goitre · Toxic multinodular goiter
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