Male-limited precocious puberty


Male-limited precocious puberty
Male-limited precocious puberty
Classification and external resources
OMIM 176410

Male-limited precocious puberty (also known as familial sexual precocity and gonadotropin-independent testotoxicosis)[1] is a form of gonadotropin-independent precocious puberty in which boys experience early onset and progression of puberty.[2] Signs of puberty can develop as early as an age of 1 year.

The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant[1] condition with a mutation of the LH receptor. Treatment is with drugs that suppress gonadal steroidogenesis, such as cyproterone acetate, ketoconazole or spironolactone and testolactone.[3]

Male-limited precocious puberty has an autosomal dominant pattern of inheritance.

References

  1. ^ a b Online 'Mendelian Inheritance in Man' (OMIM) 176410
  2. ^ Traggiai C, Stanhope R (2003). "Disorders of pubertal development". Best Pract Res Clin Obstet Gynaecol 17 (1): 41–56. doi:10.1053/ybeog.2003.0360. PMID 12758225. 
  3. ^ Reiter EO, Norjavaara E (2005). "Testotoxicosis: current viewpoint". Pediatr Endocrinol Rev 3 (2): 77–86. PMID 16361981. 

External links


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