Machine perfusion

Machine perfusion

Machine perfusion (MP) is a technique used in organ transplantation as a means of preserving the organs which are to be transplanted. To some degree, it emulates natural perfusion. So far it has mainly been used in kidney transplantation. It is an alternative to cold storage (CS). Its clinical and cost-effectiveness are still subject to research. [cite journal |author=Wight J, Chilcott J, Holmes M, Brewer N |title=The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors |journal=Health Technol Assess |year=2003 |pages=1–94 |volume=7 |issue=25 |pmid=14499050]

Hypothermic perfusion has given the longest storage time for canine kidneys with the best result being 8 day storage. [Cohen GL: "8 day kidney preservation", Ch.M. thesis, Liverpool University: 1982.] This experimental model used a storage temperature of 8°C and a Plasma Protein Fraction (PPF) based perfusate. [Cohen GL, Johnson RWG: "Perfusate buffering for 8-day canine kidney storage", "Proceedings of the European Society for Artificial Organs", vol.7 (1980), p.235-239.] The octanoic acid content of PPF was found to influence the results of preservation in five-day storage. [Cohen GL, Hunt L, Johnson RWG: "Octanoate toxicity in 5 day kidney preservation", "Cryobiology", vol.20 (1983), p.731.] Both octanoic acid and oleic acid stimulated oxygen consumption to a similar degree during hypothermic perfusion [Cohen GL, Burdett K, Johnson RWG: "Stimulation of oxygen consumption by oleic and octanoic acid during hypothermic kidney preservation", "Cryobiology", vol.22 (1985), p.615-616.] suggesting that the detrimental effect of Octanoic acid was due to direct metabolic stimulation rather than uncoupling of oxidatative phosphorylation. [Cohen GL, Burdett K, Hunt L, Johnson RWG: "Uncoupling of oxidative phosphorylation by octanoic acid during 5-day hypothermic kidney preservation", "Cryobiology", vol.21 (1984), p.699-700.]


Organ transplantation

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Perfusion — In physiology, perfusion is the process of nutritive delivery of arterial blood to a capillary bed in the biological tissue. The word is derived from the French verb perfuser meaning to pour over or through. Tests of adequate perfusion are a part …   Wikipedia

  • Non-heart-beating donation — Prior to the introduction of brain stem death into law in the mid to late 1970s, all organ transplants from cadaveric donors came from non heart beating donors (NHBD).[citation needed] Brain stem dead donors (beating heart cadavers), however, led …   Wikipedia

  • Lung transplantation — Intervention ICD 9 CM 33.5 MeSH …   Wikipedia

  • Heart–lung transplant — Intervention ICD 9 CM 33.6 MeSH …   Wikipedia

  • Organ donation — Intervention Organ donation is the donation of biological tissue or an organ of the human body, from a living or dead person to a living recipient in need of a transplantation. Transplantable organs and tissues are removed in a surgical procedure …   Wikipedia

  • Head transplant — A head transplant is a surgical operation involving the grafting of an organism s head onto the body of another. It should not be confused with another, hypothetical, surgical operation, the brain transplant. Head transplantation involves… …   Wikipedia

  • Christiaan Barnard — Christiaan Neethling Barnard Born November 8, 1922 Beaufort West, Cape Province, Union of South Africa Died September 2, 2001( …   Wikipedia

  • Hematopoietic stem cell transplantation — HSCT redirects here. For the supersonic aircraft, see High Speed Civil Transport. Hematopoietic stem cell transplantation Intervention ICD 9 CM 41.0 MeSH …   Wikipedia

  • Organ harvesting — Intervention MeSH D020858 Organ harvesting refers to the removal, preservation and use of human organs and tissue from the bodies of the recently deceased to be used in surgical transplants on the living. Though mired in ethical debate and… …   Wikipedia

  • Organ transplantation — Intervention Cosmas and Damian miraculously transplant the (black) leg of a Moor onto the (white) body of Justinian. Ditzingen, 16th century ICD 10 PCS …   Wikipedia