Sodium orthovanadate


Sodium orthovanadate
Sodium orthovanadate
Identifiers
CAS number 13721-39-6 YesY
PubChem 61671
RTECS number YW1120000
Properties
Molecular formula Na3VO4
Molar mass 183.908 g/mol
Appearance white powder
Density 2.16 g/cm³, solid
Melting point

858 °C

Solubility in water soluble
Hazards
Main hazards Harmful.
NFPA 704
NFPA 704.svg
1
2
0
Flash point Non-flammable
 YesY orthovanadate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Sodium orthovanadate is the chemical compound Na3VO4 and contains the tetrahedral VO43−.[1] It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43- ion binds reversibly to the active sites of most protein tyrosine phosphatases.

It is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. It is commonly used at a final working concentration of 1 - 10 μM. It is toxic when inhaled, swallowed or in contact with skin.

References

  1. ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Oxford: Butterworth-Heinemann. ISBN 0080379419. 
Swarup, G. et al. Biochem. Biophys. Res. Comm. 107: 1104-1109 (1982).

See also


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