Cyclamate is an
artificial sweetenerthat was discovered in 1937 at the University of Illinois by graduate student Michael Sveda.
Like many artificial sweeteners, the sweetness of cyclamate was discovered by accident. Michael Sveda was working in the lab on the synthesis of anti-fever medication. He put his
cigarettedown on the lab bench and when he put it back in his mouthhe discovered the sweet taste of cyclamate. The patent for cyclamate was purchased by DuPontbut later sold to Abbott Laboratorieswhich undertook the necessary studies and submitted a New Drug Application in 1950. Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibioticsand pentobarbital. In the US in 1958 it was designated GRAS ( Generally Recognized as Safe). Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form; one such product was named 'Sucaryl' and is still available in non-US markets. In the European Union, it is also known under the E number(additive code) E952.
Cyclamate is 30–50 times sweeter than sugar (depending on concentration; it is not a linear relationship), making it the least potent of the commercially used artificial sweeteners. Some people find it to have an unpleasant aftertaste, but generally less so than
saccharinor acesulfame potassium. It is often used synergistically with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. It is less expensive than most sweeteners, including sucralose, and is stable under heating.
Cyclamate is the
sodiumor calcium saltof cyclamic acid(cyclohexanesulfamic acid). It is prepared by the sulfonationof cyclohexylamine; this can be accomplished by reacting cyclohexylamine with either sulfamic acidor sulfur trioxide.
In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce
cyclohexylamine, a compound suspected to have some chronic toxicity in animals. Further research resulted in a 1969 study which found the common 10:1 cyclamate:saccharin mixture to increase the incidence of bladder cancerin rats. The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels of humans ingesting 350 cans of diet soda per day, developed bladder tumors. Other studies implicated cyclohexylamine in testicular atrophy in mice. On October 18, 1969, the Food and Drug Administrationciting the Delaney Amendment banned its sale in the United Statesand the United Kingdomfollowed suit the next year. Abbott Laboratories claimed that its own studies were unable to reproduce the 1969 study's results, and in 1973, Abbott petitioned the FDA to lift the ban on cyclamate. This petition was eventually denied in 1980 by FDA Commissioner Jere Goyan. Abbott Labs, together with the Calorie Control Council(a political lobby representing the diet foods industry), filed a second petition in 1982. Although the FDA has stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States. The petition is now held in abeyance (it is not actively being considered) though whether this is at the request of Abbott Labs themselves or because the petition is considered to be insufficient by the FDA is unclear. Cyclamate is approved as a sweetener in more than 55 countries: for example, the brand-name beverage sweetener Sweet'N Low, which contains only dextrose, saccharin, cream of tartar, and calcium silicatein the United States, contains cyclamate in Canada(where saccharin is banned except for diabetic usage). Similarly, [http://www.sugartwin.com/index.cfm Sugar Twin] , the brand-name cyclamate sweetener in Canada, contains saccharin in the United States [Comparison at Sugar Twin Canada website - http://www.sugartwin.com/pi_ing.cfm] .(October 1969)
One reported effect in animal studies (mice and primates) is irreversible
testicular atrophyand an apparent impact on seminal vesiclefunction.
However, possible negative impacts on male reproductive ability and/or function may lie outside the remits of committees tasked to determine the safety of a product based only on its expected impact on life expectancy and/or cancer rates. Since a reduction in male testosterone levels is thought to be associated with a "reduced" incidence of certain cancersFact|date=September 2008 (such as testicular cancer), and an "increased" life expectancy,Fact|date=September 2008 a substance that damages testosterone production may be easier to be classified as safe when life expectancy and carcinogenicity are the deciding criteria.Fact|date=September 2008
Since cyclamates appear to affect cells involved in the production of spermatozoa, the question has also been raised as to whether they may also be capable of damaging male reproductive DNA. There does not yet seem to be any direct evidence either for or against this.
Cyclamate Sweetener Brands
* [http://www.sugartwin.com/index.cfm Sugar Twin] (Canada)
* http://ec.europa.eu/food/fs/sc/scf/out53_en.pdf European Commission Revised Opinion On Cyclamic Acid
* http://www.cfsan.fda.gov/~dms/opa-abey.html US FDA Petitions Currently Held in Abeyance
* http://environmentalchemistry.com/yogi/chemicals/cn/Cyclohexanesulfamic%A0acid,%A0monosodium%A0salt.html List of other chemical and brand names for cyclamate
* http://www.hermesetas.com/data/en/specialised/sweeteners/history.php A brief history of sweeteners, including the discovery of cyclamate
* http://www.assugrin.ch/daten_f/maison.php Assugrin's website (French)
* http://www.foodcomm.org.uk/press_97_cyclams.htm concerns over potential "testicular wasting" in male users
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Look at other dictionaries:
Cyclamate — de sodium Général Nom IUPAC sodium N cyclohexylsulfamate Synonymes … Wikipédia en Français
cyclamate — ● cyclamate nom masculin Dénomination commune d un édulcorant de synthèse. cyclamate [siklamat] n. m. ÉTYM. 1957; de 2. cyclo , et suff. de sulfamate. ❖ ♦ Chim. || Cyclamate de sodium (cyclohexylsulfamate de sodium) : édulcorant de synthèse (→… … Encyclopédie Universelle
Cyclamate — Cyclamate, Singular Cyclamat das, s, Salze der Cyclohexylsulfaminsäure; künstliche, kochbeständige Süßstoffe, die rasch durch Nieren und Darm ausgeschieden werden. Wichtig ist z. B. das Natriumcyclamat mit einem Süßwert von 30 … Universal-Lexikon
cyclamate — [sī′klə māt΄, sik′ləmāt΄] n. [cycl(ohexylsulph)amate < cyclohexyl, C6H11, a monovalent radical + sulfamate, ester of sulfamic acid (HSO3NH2)] a synthetic salt derived from an organic acid, C6H11NHSO3H, esp. the sodium or calcium salt, with an… … English World dictionary
cyclamate — A salt or ester of cyclamic acid; the calcium and sodium are noncaloric artificial sweetening agents. * * * cy·cla·mate sī klə .māt, mət n an artificially prepared salt of sodium or calcium used esp. formerly as a sweetener but now largely… … Medical dictionary
cyclamate — /suy kleuh mayt , sik leuh /, n. any of several chemical compounds used as a noncaloric sweetening agent in foods and beverages: banned by the FDA in 1970 as a possible carcinogen. [1950 55; CYCLAM(IC ACID) + ATE2] * * * ▪ chemistry… … Universalium
cyclamate — n. either of two compounds, sodium or calcium cyclamate, that are thirty times as sweet as sugar and, unlike saccharin, stable to heat. Cyclamates were used as sweetening agents in the food industry until 1969, when their use was banned because… … The new mediacal dictionary
cyclamate — ciklamatas statusas T sritis chemija apibrėžtis Ciklamo rūgšties Na arba Ca druska, dirbtinis saldiklis. atitikmenys: angl. cyclamate rus. цикламат … Chemijos terminų aiškinamasis žodynas
cyclamate — noun Etymology: cyclohexyl sulfamate Date: 1954 an artificially prepared salt of sodium or calcium used especially formerly as a sweetener … New Collegiate Dictionary
cyclamate — noun any salt or ester of cyclamic acid, especially the sodium and calcium salts, which have been used as artificial sweeteners Syn: E952, sweetener … Wiktionary