Diagrammatic sections of the uterine mucous membrane: A. The non-pregnant uterus. B. Decidua parietalis; the mucus membrane in the pregnant uterus and not beneath the placenta.
Sectional plan of the gravid uterus in the third and fourth month.
Gray's subject #12 59
MeSH Decidua
Code TE E6.

Decidua is the term for the uterine lining (endometrium) during a pregnancy, which forms the maternal part of the placenta. It is formed under the influence of progesterone and forms highly-characteristic cells.



The word comes from the Latin deciduus, meaning falling off or shedding.


After ovulation, in mammals, the endometrial lining becomes transformed into a secretory lining in preparation of accepting the embryo. Without implantation, the secretory lining will be absorbed (estrous cycle) or shed (menstrual cycle).

With implantation the lining now termed decidua evolves further during the pregnancy.

The decidua is shed during the parturition process.


Different layers of the deciduas have been described:

  • a compact outer layer (stratum compactum)
  • an intermediate layer (stratum spongiosum)
  • a boundary layer adjacent to the myometrium ('Stratum Basalis').

That part of the decidua that interacts with the trophoblast is the decidua basalis (also called decidua placentalis). The remainder of the decidua is termed the decidua parietalis or decidua vera. Also, there is the decidua capsularis, which grows over the embryo on the luminal side, enclosing it into the endometrium and surrounding the embryo together with decidua basalis.

Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain.

The decidua has a histologically-distinct appearance, displaying large polygonal decidual cells in the stroma. These are enlarged endometrial stromal cells, which resemble epithelium (and are referred to as "epithelioid").

Formation of a specialized decidua is called decidualization, which is a special property of endometrium seen only in hemochorial placentation.

Decidualization includes the process of differentiation of the spindle-shape stromal fibroblasts into the plump secretory decidual cells, which create a pericellular extracellular matrix rich in fibronectin and laminin (similar to epithelial cells).

Vascularity, as well as vascular permeability, is enhanced in the decidualizing endometrium.

Its leukocyte population is distinct, with the presence of large endometrial granular leukocytes being predominant, while polynuclear leukocytes and B-cells are scant.

The large granular lymphocytes (CD56 bright) are called "uterine NK cells" or "uNK cells" in mice, and "decidual NK cells" or "dNK cells" in humans.

The border to the trophoblast is called Nitabuch’s layer.


As the maternal interface to the embryo the decidua participates in the exchanges of nutrition, gas, and waste with the gestation. It also protects the pregnancy from the maternal immune system. Further, the decidua has to allow a very controlled invasion of the trophoblast.

In invasive placental disorders like placenta accreta decidualization have been consistently found to be deficient.

Hormone production

The decidua secretes hormones, growth factors, and cytokines. It has receptors for estrogen, progesterone, growth hormone, and others.

Among its products are hormones commonly associated with other organs such as cortisol, CRF, GnRH, prolactin, and relaxin. Decidual prolactin is not under dopaminergic control.

Pregnancy protein 14 (PP-14), also called placental protein 12, and Insulin-like growth factor-binding protein 1(IGFBP1) appear to be specific products of the secretory and decidual lining.

Other factors released include interleukin-15 and vascular endothelial growth factor (VEGF). A reasonable understanding of the role and interplay of these hormones and factors has not been evolved.


Micrograph of decidua in a lymph node. H&E stain.
  • In case of an extrauterine pregnancy, the endometrium nevertheless becomes decidualized. A woman may shed the lining in the form of a decidual cast, which may be mistaken as a miscarriage, when, in fact, the ectopic still persists.
  • A decidual reaction can be observed in tissue of the peritoneum and ovary during a pregnancy, and represents a response of stromal tissue to progesterone.
  • Decidua in a lymph node may mimic metastatic carcinoma.[1]


A long-lasting infection of the decidua, chronic deciduitis, is associated with preterm labour.[2]

Additional images


  1. ^ Wu, DC.; Hirschowitz, S.; Natarajan, S. (May 2005). "Ectopic decidua of pelvic lymph nodes: a potential diagnostic pitfall.". Arch Pathol Lab Med 129 (5): e117-20. doi:10.1043/1543-2165(2005)129e117:EDOPLN2.0.CO;2. PMID 15859655. 
  2. ^ Edmondson, N.; Bocking, A.; Machin, G.; Rizek, R.; Watson, C.; Keating, S.. "The prevalence of chronic deciduitis in cases of preterm labor without clinical chorioamnionitis.". Pediatr Dev Pathol 12 (1): 16–21. doi:10.2350/07-04-0270.1. PMID 18171100. 

External links

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Look at other dictionaries:

  • Decidua — Saltar a navegación, búsqueda Secciones diagramáticas de la mucosa uterina: A. útero no grávido. B. útero grávido. En obstetricia se usa el término decidua para la recubierta uterina (endometrio) específicamente durante el gestación, el cual da… …   Wikipedia Español

  • decidua — f. embriol. Caduca uterina. Medical Dictionary. 2011. decidua mucosa en la que se transforma el …   Diccionario médico

  • decidua — [dē sij′o͞o ə] n. pl. deciduae [dē sij′o͞oē] or deciduas [ModL ( membrana) decidua, deciduous (membrane), orig. fem. of L deciduus: see DECIDUOUS] a mucous membrane lining the uterus during pregnancy, cast off at childbirth decidual adj …   English World dictionary

  • Decidua — De*cid u*a (?; 135), n. [NL., fr. L. deciduus. See {Deciduous}.] (Anat.) The inner layer of the wall of the uterus, which envelops the embryo, forms a part of the placenta, and is discharged with it. [1913 Webster] || …   The Collaborative International Dictionary of English

  • Decidŭa — (lat., abfallende Haut), die verdickte Schleimhaut der Gebärmutter, löst sich bei der Menstruation in ihren oberflächlichen Schichten ab und wird mit dem unbefruchteten Ei ausgestoßen (D. menstrualis). Ist jedoch ein befruchtetes Ei in die… …   Meyers Großes Konversations-Lexikon

  • Decidua — Decidŭa (lat.), die äußere oder hinfällige Haut des Embryos der höhern Säugetiere (Deciduata, s.d.), aus der veränderten Gebärmutterschleimhaut hervorgehend …   Kleines Konversations-Lexikon

  • Decidua —   [zu lateinisch deciduus »abfallend«] die, , Siebhaut, die hormonell für die Aufnahme des Keims entsprechend umgebildete, bei der Menstruation und der Geburt unter größeren Blutungen wieder abgestoßene obere Schicht der Gebärmutterschleimhaut;… …   Universal-Lexikon

  • decídua — s. f. O que fica no útero e é expulso depois do parto. = PÁREAS, SECUNDINAS   ‣ Etimologia: feminino de decíduo …   Dicionário da Língua Portuguesa

  • decidua — SYN: deciduous membrane. [L. deciduus, falling off (qualifying membrana, membrane, understood)] d. basalis the area of endometrium between the implanted chorionic vesicle and the myometrium, which develops into the maternal part of the place …   Medical dictionary

  • decidua — n. the modified mucous membrane that lines the wall of the uterus during pregnancy and is shed with the afterbirth at parturition (see endometrium). There are three regions: the decidua capsularis, a thin layer that covers the embryo; the decidua …   The new mediacal dictionary