Histone H3


Histone H3

protein
Name = H3 histone, family 3A
caption =


width =
HGNCid = 4764
Symbol = H3F3A
AltSymbols = H3F3
EntrezGene = 3020
OMIM = 601128
RefSeq = NM_002107
UniProt = Q66I33
PDB =
ECnumber =
Chromosome = 1
Arm = q
Band = 41
LocusSupplementaryData =
protein
Name = H3 histone, family 3B (H3.3B)
caption =


width =
HGNCid = 4765
Symbol = H3F3B
AltSymbols =
EntrezGene = 3021
OMIM = 601058
RefSeq = NM_005324
UniProt = P84243
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 25
LocusSupplementaryData =

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure.

The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Methylation of lysine9 has been associated with gene silencing and the formation of relatively inactive regions of DNA known as heterochromatin. Acetylation of histone H3 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs). Acetylation of lysine14 is commonly seen in genes that are being actively transcribed into RNA. Other histone proteins involved:
H1
H2A
H2B
H4

ee also

* Nucleosome
* Histone
* Chromatin


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Look at other dictionaries:

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  • histone — [ istɔn ] n. f. • 1904; histon 1890; du gr. histos « tissu » ♦ Biochim. Protéine basique du noyau cellulaire. Les histones forment des complexes avec l A. D. N. et interviennent dans l expression du message génétique. ● histone nom féminin… …   Encyclopédie Universelle

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  • Histone — Histone, mit der DNA zu Nucleohistonen verbundene, arginin und lysinreiche Proteine; spielen unter den basischen Proteinen, die die Eukaryoten DNA neutralisieren, eine herausragende Rolle. H. hemmen Replikation und Transkription …   Deutsch wörterbuch der biologie

  • histone — 1885, from Ger. histon (1884); see HISTO (Cf. histo ) + ONE (Cf. one) …   Etymology dictionary

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  • Histone — In biology, histones are the chief protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long. For example, each human… …   Wikipedia

  • Histone — Structure d un nucléosome. On distingue les extrémités N terminales des histones se projetant à l extérieur de la partie globulaire du nucléosome Les histones sont des protéines très riches en acides aminés basiques, que l on trouve dans le noyau …   Wikipédia en Français

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  • Histone H1 — protein Name = H1 histone family, member 0 caption = HGNCid = 4714 Symbol = H1F0 AltSymbols = H1FV EntrezGene = 3005 OMIM = 142708 RefSeq = NM 005318 UniProt = P07305 PDB = ECnumber = Chromosome = 22 Arm = q Band = 13.1 LocusSupplementaryData =… …   Wikipedia


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