Histone H1


Histone H1

protein
Name = H1 histone family, member 0
caption =



HGNCid = 4714
Symbol = H1F0
AltSymbols = H1FV
EntrezGene = 3005
OMIM = 142708
RefSeq = NM_005318
UniProt = P07305
PDB =
ECnumber =
Chromosome = 22
Arm = q
Band = 13.1
LocusSupplementaryData =

Histone H1 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. A variant of the histone H1 protein is the histone H5, which has a similar structure and function, but is only found in avian erythrocytes, which unlike mammals have nuclei.

Featuring a central globular domain and long C and N terminal tails H1 is involved with the packing of the 'beads on a string' structure into the '30nm solenoid' structure.

H1 is present in half the amount of the other four histones. This is because unlike the other histones, H1 does not make up the nucleosome 'bead'. Instead, it sits on top of the structure, keeping in place the DNA that has wrapped around the nucleosome. Specifically, the H1 protein binds to the "linker DNA" (approximately 80 nucleotides in length) region between the histone beads, helping stabilize the zig-zagged 30nm chromatin fiber.

H1 histone seals off the nucleosome at the location at which the linker DNA enters and leaves.


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Look at other dictionaries:

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  • histone — [ istɔn ] n. f. • 1904; histon 1890; du gr. histos « tissu » ♦ Biochim. Protéine basique du noyau cellulaire. Les histones forment des complexes avec l A. D. N. et interviennent dans l expression du message génétique. ● histone nom féminin… …   Encyclopédie Universelle

  • Histone — Histone, stickstoffreiche Eiweißkörper von entschieden basischem Charakter, die durch Alkalien gefällt werden, im Überschuß aber meist löslich sind. Sie lösen sich leicht in Säuren. H. kommen als solche nicht vor, bilden aber, gepaart mit einer… …   Meyers Großes Konversations-Lexikon

  • Histone — Histone, mit der DNA zu Nucleohistonen verbundene, arginin und lysinreiche Proteine; spielen unter den basischen Proteinen, die die Eukaryoten DNA neutralisieren, eine herausragende Rolle. H. hemmen Replikation und Transkription …   Deutsch wörterbuch der biologie

  • histone — 1885, from Ger. histon (1884); see HISTO (Cf. histo ) + ONE (Cf. one) …   Etymology dictionary

  • histone — [his′tōn΄] n. [< Gr histos (see HISTO ) + ONE] any of a group of strongly basic, simple proteins found in the nucleus of cells and associated with DNA: they are sometimes poisonous when injected into an animal and prevent the clotting of blood …   English World dictionary

  • Histone — In biology, histones are the chief protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long. For example, each human… …   Wikipedia

  • Histone — Structure d un nucléosome. On distingue les extrémités N terminales des histones se projetant à l extérieur de la partie globulaire du nucléosome Les histones sont des protéines très riches en acides aminés basiques, que l on trouve dans le noyau …   Wikipédia en Français

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  • Histone H3 — protein Name = H3 histone, family 3A caption = width = HGNCid = 4764 Symbol = H3F3A AltSymbols = H3F3 EntrezGene = 3020 OMIM = 601128 RefSeq = NM 002107 UniProt = Q66I33 PDB = ECnumber = Chromosome = 1 Arm = q Band = 41 LocusSupplementaryData =… …   Wikipedia


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