Interleukin 1, alpha, also known as IL1A, is a human gene.

section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [cite web | title = Entrez Gene: IL1A interleukin 1, alpha| url =| accessdate = ]

ee also

* Interleukin 1


Further reading

citations =
*cite journal | author=Verweij CL, Bayley JP, Bakker A, Kaijzel EL |title=Allele specific regulation of cytokine genes: monoallelic expression of the IL-1A gene. |journal=Adv. Exp. Med. Biol. |volume=495 |issue= |pages= 129–39 |year= 2002 |pmid= 11774556 |doi=
*cite journal | author=Griffin WS, Mrak RE |title=Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. |journal=J. Leukoc. Biol. |volume=72 |issue= 2 |pages= 233–8 |year= 2002 |pmid= 12149413 |doi=
*cite journal | author=Arend WP |title=The balance between IL-1 and IL-1Ra in disease. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 323–40 |year= 2003 |pmid= 12220547 |doi=
*cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=
*cite journal | author=Schmidt DR, Kao WJ |title=The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function. |journal=Biomaterials |volume=28 |issue= 3 |pages= 371–82 |year= 2007 |pmid= 16978691 |doi= 10.1016/j.biomaterials.2006.08.041
*cite journal | author=Huynh-Ba G, Lang NP, Tonetti MS, Salvi GE |title=The association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: a systematic review. |journal=J. Clin. Periodontol. |volume=34 |issue= 4 |pages= 305–17 |year= 2007 |pmid= 17378887 |doi= 10.1111/j.1600-051X.2007.01055.x

External links


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