IL1A


IL1A

Interleukin 1, alpha, also known as IL1A, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [cite web | title = Entrez Gene: IL1A interleukin 1, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3552| accessdate = ]

ee also

* Interleukin 1

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Verweij CL, Bayley JP, Bakker A, Kaijzel EL |title=Allele specific regulation of cytokine genes: monoallelic expression of the IL-1A gene. |journal=Adv. Exp. Med. Biol. |volume=495 |issue= |pages= 129–39 |year= 2002 |pmid= 11774556 |doi=
*cite journal | author=Griffin WS, Mrak RE |title=Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. |journal=J. Leukoc. Biol. |volume=72 |issue= 2 |pages= 233–8 |year= 2002 |pmid= 12149413 |doi=
*cite journal | author=Arend WP |title=The balance between IL-1 and IL-1Ra in disease. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 323–40 |year= 2003 |pmid= 12220547 |doi=
*cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines. |journal=Mini reviews in medicinal chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=
*cite journal | author=Schmidt DR, Kao WJ |title=The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function. |journal=Biomaterials |volume=28 |issue= 3 |pages= 371–82 |year= 2007 |pmid= 16978691 |doi= 10.1016/j.biomaterials.2006.08.041
*cite journal | author=Huynh-Ba G, Lang NP, Tonetti MS, Salvi GE |title=The association of the composite IL-1 genotype with periodontitis progression and/or treatment outcomes: a systematic review. |journal=J. Clin. Periodontol. |volume=34 |issue= 4 |pages= 305–17 |year= 2007 |pmid= 17378887 |doi= 10.1111/j.1600-051X.2007.01055.x

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Интерлейкин 1, альфа — Обозначения Символы IL1A; IL1 Entrez Gene …   Википедия

  • Haematopoiesis — Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Haematopoiesis (from Ancient Greek: αἷμα, blood ; ποιεῖν to make ) (or hematopoiesis in the United States; sometimes also haemopoiesis or… …   Wikipedia

  • Cytokine — Cytokines (Greek cyto , cell; and kinos, movement) are small cell signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used… …   Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • Interleukin 1 — protein Name = interleukin 1, alpha caption = Crystal structure of IL 1a (PDB|2ILA). width = 250 HGNCid = 5991 Symbol = IL1A AltSymbols = IL1; IL 1A; IL1; IL1 ALPHA; IL1F1 EntrezGene = 3552 OMIM = 147760 RefSeq = NM 000575 UniProt = P01583 PDB =… …   Wikipedia

  • Interleukin 6 — (interferon, beta 2) PDB rendering based on 1ALU …   Wikipedia

  • Peginterferon alfa-2a — Clinical data AHFS/Drugs.com Consumer Drug Information MedlinePlus …   Wikipedia

  • Osteopontin — Secreted phosphoprotein 1 Rendering based on PDB 3CXD …   Wikipedia

  • Leukemia inhibitory factor — (cholinergic differentiation factor) PDB rendering based on 1LKI …   Wikipedia

  • CCL2 — For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene. Chemokine (C C motif) ligand 2 PDB rendering based on 1dok …   Wikipedia