Toxicophore

Toxicophore

A toxicophore is a feature or group within a chemical structure that is thought to be responsible for the toxic properties, either directly or via metabolic activation.

A toxic substance exerts its toxicity through interaction (covalent bonding or oxidation) with a cellular macromolecule, such as a protein or DNA. This causes changes in the normal cellular biochemistry and physiology eliciting toxic effects.Occasionally, the toxicophore requires bioactivation, modified by an enzyme, to produce a more reactive chemical species that is able to covalently bind to cellular macromolecules. Generally, different chemical compounds that contain the same toxicophore elicit similar toxic effects within the same organ system or area of the body. [cite book
last = Williams
first = D.P.
coauthors = Naisbitt, D.J.
title = Toxicophores: Groups and Metabolic Routes Associated with Increased Safety Risk
year = 2002
pages = pp. 104-115]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • toxicophore — [tɔksikɔfɔʀ] adj. ÉTYM. 1876; de toxico , et phore. ❖ ♦ Didactique. 1 Qui produit des substances toxiques (animaux, plantes). 2 ( …   Encyclopédie Universelle

  • toxicophore — (entrée créée par le supplément) (to ksi ko fo r ) adj. Qui porte un venin. Poissons toxicophores. ÉTYMOLOGIE    Du grec, poison, toxique, et du grec, qui porte …   Dictionnaire de la Langue Française d'Émile Littré

  • toxicofor — TOXICOFÓR, OÁRE, toxicofori, oare, adj. (Despre vieţuitoare) Care conţine substanţe toxice (pentru om). – Din fr. toxicophore. Trimis de LauraGellner, 28.06.2004. Sursa: DEX 98  toxicofór adj. m., pl. toxicofóri; f. sg. toxicofóră …   Dicționar Român

  • Toxin — This article is about the class of poisonous substances. For other uses, see Toxin (disambiguation). Universal warning symbol used to indicate toxic substances or environments A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous… …   Wikipedia

  • Toxicity — This article is about the scientific term. For other uses of toxicity and toxic, see Toxicity (disambiguation). The skull and crossbones is a common symbol for toxicity. Toxicity is the degree to which a substance can damage a living or non… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”