Hemoglobin C

Hemoglobin C

Hemoglobin C (abbreviated as "Hb C" or "HbC") is an abnormal hemoglobin with substitution of a lysine residue for glutamic acid residue at the 6th position of the β-globin chain. [ [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=141900&a=141900_AllelicVariant0038 Hemoglobin C (HBB, GLU6LYS)] ] This mutated form reduces the normal plasticity of host erythrocytes causing a hemoglobinopathy. In those who are heterozygous for the mutation, about 28–44% of total hemoglobin (Hb) is HbC, and no anemia develops. In homozygotes, nearly all Hb is in the HbC form, resulting in moderate normocytic hemolytic anemia. Target cells, microspherocytes and HbC crystals are found in a blood smear from a homozygous patient. Individuals heterozygous for both HbC and Hb S (Hb SC disease) or for HbC and thalassemia are known, and have atypical hemolytic anemias; sickling is enhanced in Hb SC disease. Hemoglobin C is found predominantly in West Africa and has been shown to protect against severe malaria.

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См. также в других словарях:

  • Hemoglobin — Hemoglobin, human, adult (heterotetramer, (αβ)2) Structure of human hemoglobin. The protein s α and β subunits are in red and blue, and the iron containing heme groups in green. Fro …   Wikipedia

  • hemoglobin C — n an abnormal hemoglobin that differs from hemoglobin A in having a lysine residue substituted for the glutamic acid residue at position 6 in two of the four polypeptide chains making up the hemoglobin molecule * * * a common abnormal hemoglobin… …   Medical dictionary

  • Hemoglobin A2 — is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is found in small quantity in normal human blood. Hemoglobin A2 may be increased in beta thalassemia.External links* …   Wikipedia

  • hemoglobin A — n the hemoglobin in the red blood cells of the normal human adult that consists of two alpha chains and two beta chains * * * normal adult hemoglobin, composed of two α and two β chains, α2Aβ2A …   Medical dictionary

  • hemoglobin F — hemoglobin F. = fetal hemoglobin (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemoglobin F — n FETAL HEMOGLOBIN * * * fetal h …   Medical dictionary

  • Hemoglobin — Hem o*glo bin, n. [Hemo + globe.] (Physiol.) The normal coloring matter of the red blood corpuscles of vertebrate animals. It is composed of hematin and globulin, and is also called {h[ae]matoglobulin}. In arterial blood, it is always combined… …   The Collaborative International Dictionary of English

  • hemoglobin F — hemoglobin F. См. гемоглобин F. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemoglobin — hemoglobin. См. гемоглобин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemoglobin C — hemoglobin C. См. гемоглобин С. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.


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