Nephron


Nephron
Nephron
Gray1128.png
Nephron of the kidney without juxtaglomerular apparatus
Latin nephroneum
Gray's subject #253 1221
Precursor Metanephric blastema (intermediate mesoderm)
MeSH Nephrons

Nephron (from Greek νεφρός - nephros, meaning "kidney") is the basic structural and functional unit of the kidney. Its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[1] In humans, a normal kidney contains 800,000 to 1.5 million nephrons.[2]

Contents

Types of nephrons

Two general classes of nephrons are cortical nephrons and juxtamedullary nephrons, both of which are classified according to the length of their associated Loop of Henle and location of their renal corpuscle. All nephrons have their renal corpuscles in the cortex. Cortical nephrons have their Loop of Henle in the renal medulla near its junction with the renal cortex, while the Loop of Henle of juxtamedullary nephrons is located deep in the renal medulla; they are called juxtamedullary because their renal corpuscle is located near the medulla (but still in the cortex). The nomenclature for cortical nephrons varies, with some sources distinguishing between superficial cortical nephrons and midcortical nephrons, depending on where their corpuscle is located within the cortex.[3]

The majority of nephrons are cortical. Cortical nephrons have a shorter loop of Henle compared to juxtamedullary nephrons. The longer loop of Henle in juxtamedullary nephrons create a hyperosmolar gradient that allows for the creation of concentrated urine.[4]

Anatomy

Each nephron is composed of an initial filtering component (the "renal corpuscle") and a tubule specialized for reabsorption and secretion (the "renal tubule"). The renal corpuscle filters out large solutes from the blood, delivering water and small solutes to the renal tubule for modification.[citation needed]

Renal corpuscle

Composed of a glomerulus and the Bowman's capsule, the renal corpuscle (or Malpighian corpuscle) is the beginning of the nephron. It is the nephron's initial filtering component.[citation needed]

The glomerulus is a capillary tuft that receives its blood supply from an afferent arteriole of the renal circulation. The glomerular blood pressure provides the driving force for water and solutes to be filtered out of the blood and into the space made by Bowman's capsule. The remainder of the blood (only approximately 1/5 of all plasma passing through the kidney is filtered through the glomerular wall into the Bowman's capsule) passes into the efferent arteriole.The diameter of efferent arteriole is comparatively less than that of afferent arteriole. It then moves into the vasa recta, which are only found in juxtamedullary nephrons and not cortical nephrons. The vasa recta are collecting capillaries intertwined with the convoluted tubules through the interstitial space, in which the reabsorbed substances will also enter. This then combines with efferent venules from other nephrons into the renal vein, and rejoins the main bloodstream.[citation needed]

The Bowman's capsule, also called the glomerular capsule, surrounds the glomerulus. It is composed of a visceral inner layer formed by specialized cells called podocytes, and a parietal outer layer composed of a single layer of flat cells called simple squamous epithelium. Fluids from blood in the glomerulus are filtered through the visceral layer of podocytes, and the resulting glomerular filtrate is further processed along the nephron to form urine.[citation needed]

Renal tubule

Renal tubule
Latin tubulus renalis
Gray's subject #253 1223

The renal tubule is the portion of the nephron containing the tubular fluid filtered through the glomerulus.[5] After passing through the renal tubule, the filtrate continues to the collecting duct system, which is not part of the nephron.[citation needed]

The components of the renal tubule are:

Functions

The nephron carries out nearly all of the kidney's functions. Most of these functions concern the reabsorption and secretion of various solutes such as ions (e.g., sodium), carbohydrates (e.g., glucose), and amino acids (e.g., glutamate). Properties of the cells that line the nephron change dramatically along its length; consequently, each segment of the nephron has highly specialized functions.[citation needed]

The proximal tubule as a part of the nephron can be divided into an initial convoluted portion and a following straight (descending) portion.[6] Fluid in the filtrate entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes (primarily glucose and amino acids).[citation needed]

The loop of Henle, also called the nephron loop, is a U-shaped tube that extends from the proximal tubule. It consists of a descending limb and ascending limb. It begins in the cortex, receiving filtrate from the proximal convoluted tubule, extends into the medulla as the descending limb, and then returns to the cortex as the ascending limb to empty into the distal convoluted tubule. The primary role of the loop of Henle is to concentrate the salt in the interstitium, the tissue surrounding the loop.[citation needed]

Considerable differences distinguish the descending and ascending limbs of the loop of Henle. The descending limb is permeable to water and noticeably less impermeable to salt, and thus only indirectly contributes to the concentration of the interstitium. As the filtrate descends deeper into the hypertonic interstitium of the renal medulla, water flows freely out of the descending limb by osmosis until the tonicity of the filtrate and interstitium equilibrate. Longer descending limbs allow more time for water to flow out of the filtrate, so longer limbs make the filtrate more hypertonic than shorter limbs.[citation needed]

Unlike the descending limb, the ascending limb of Henle's loop[disambiguation needed ] is impermeable to water, a critical feature of the countercurrent exchange mechanism employed by the loop. The ascending limb actively pumps sodium out of the filtrate, generating the hypertonic interstitium that drives countercurrent exchange. In passing through the ascending limb, the filtrate grows hypotonic since it has lost much of its sodium content. This hypotonic filtrate is passed to the distal convoluted tubule in the renal cortex.[citation needed]

The distal convoluted tubule has a different structure and function to that of the proximal convoluted tubule. Cells lining the tubule have numerous mitochondria to produce enough energy (ATP) for active transport to take place. Much of the ion transport taking place in the distal convoluted tubule is regulated by the endocrine system. In the presence of parathyroid hormone, the distal convoluted tubule reabsorbs more calcium and excretes more phosphate. When aldosterone is present, more sodium is reabsorbed and more potassium excreted. Atrial natriuretic peptide causes the distal convoluted tubule to excrete more sodium. In addition, the tubule also secretes hydrogen and ammonium to regulate pH.[citation needed]

After traveling the length of the distal convoluted tubule, only about 1% of water remains, and the remaining salt content is negligible.[citation needed]

Collecting duct system

Each distal convoluted tubule delivers its filtrate to a system of collecting ducts, the first segment of which is the collecting tubule. The collecting duct system begins in the renal cortex and extends deep into the medulla. As the urine travels down the collecting duct system, it passes by the medullary interstitium which has a high sodium concentration as a result of the loop of Henle's countercurrent multiplier system.[citation needed]

Though the collecting duct is normally impermeable to water, it becomes permeable in the presence of antidiuretic hormone (ADH). ADH affects the function of aquaporins, resulting in the reabsorption of water molecules as it passes through the collecting duct. Aquaporins are membrane proteins that selectively conduct water molecules while preventing the passage of ions and other solutes. As much as three-quarters of the water from urine can be reabsorbed as it leaves the collecting duct by osmosis. Thus the levels of ADH determine whether urine will be concentrated or diluted. An increase in ADH is an indication of dehydration, while water sufficiency results in low ADH allowing for diluted urine.[citation needed]

Lower portions of the collecting organ are also permeable to urea, allowing some of it to enter the medulla of the kidney, thus maintaining its high concentration (which is very important for the nephron).[citation needed]

Urine leaves the medullary collecting ducts through the renal papillae, emptying into the renal calyces, the renal pelvis, and finally into the urinary bladder via the ureter.[citation needed]

Because it has a different origin during the development of the urinary and reproductive organs than the rest of the nephron, the collecting duct is sometimes not considered a part of the nephron. Instead of originating from the metanephrogenic blastema, the collecting duct originates from the ureteric bud.[citation needed]

Juxtaglomerular apparatus

The juxtaglomerular apparatus is a specialized region of the nephron responsible for production and secretion of the enzyme renin, involved in the renin-angiotensin system. This apparatus occurs near the site of contact between the thick ascending limb and the afferent arteriole. It contains three components: the macula densa, juxtaglomerular cells, and extraglomerular mesangial cells.[citation needed]

Clinical relevance

Because of its importance in body fluid regulation, the nephron is a common target of drugs that treat high blood pressure and edema. These drugs, called diuretics, inhibit the ability of the nephron to retain water, thereby increasing the amount of urine produced.[citation needed]

Additional images

main point and land

See also

References

  1. ^ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1. 
  2. ^ Guyton, Arthur C.; Hall, John E. (2006). Textbook of Medical Physiology. Philadelphia: Elsevier Saunders. p. 310. ISBN 0-7216-0240-1. 
  3. ^ Physiology at MCG 7/7ch03/7ch03p16
  4. ^ Jameson, J. Larry & Loscalzo, Joseph (2010). Harrison's Nephrology and Acid-Base Disorders. McGraw-Hill Professional. p. 3. ISBN 9780071663397. http://books.google.com/books?id=yoeXSV8O2wUC&pg=PA3. 
  5. ^ Ecology & Evolutionary Biology - University of Colorado at Boulder. "The Kidney Tubule I: Urine Production." URL: http://www.colorado.edu/eeb/web_resources/cartoons/nephrex1.html. Accessed on: March 6, 2007.
  6. ^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 743. ISBN 1-4160-2328-3. 

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Look at other dictionaries:

  • néphron — [ nefrɔ̃ ] n. m. • 1954; du gr. nephros ♦ Physiol., anat. Unité anatomique et fonctionnelle du rein, constituée par un glomérule rénal et les tubes rénaux qui s y rattachent. Un rein humain comprend environ 1 million de néphrons. ● néphron nom… …   Encyclopédie Universelle

  • Nephron — Nephron, als blind geschlossenes Rohr aus dem ⇒ Malpighi Körperchen und dem sich anschließenden ⇒ Nierenkanälchen zusammengesetzte anatomische und funktionelle Einheit der ⇒ Niere der Wirbeltiere. Im N. erfolgt die Bildung des ⇒ Harns. ⊙ Nephron… …   Deutsch wörterbuch der biologie

  • nephron — (n.) 1932, from Ger. nephron (1924), from Gk. nephros kidney, from PIE *negwhro kidney (Cf. L. nefrones, O.N. nyra, Du. nier, Ger. Niere kidney ) …   Etymology dictionary

  • nephron — [nef′rän΄, nef′rən] n. [Ger < Gr nephros: see NEPHRO ] a single urinary tubule in the vertebrate kidney …   English World dictionary

  • Néphron — Le néphron est l unité structurale et fonctionnelle du rein. Il permet la formation d urine. Un rein humain adulte en compte entre 900 000 et 1,6 million. Sommaire 1 Embryologie 2 Structure 2.1 Le glomérule …   Wikipédia en Français

  • Nephron — Ein Nephron (von griech. νεφρός Niere) ist die funktionelle Untereinheit der Niere. Es besteht aus: dem Nierenkörperchen (Malpighi Körperchen, benannt nach Marcello Malpighi) und dem daran angeschlossenen Nierenkanälchen (Tubulus). Jede Niere… …   Deutsch Wikipedia

  • nephron — /nef ron/, n. Anat., Zool. the filtering and excretory unit of the kidney, consisting of the glomerulus and tubules. [1930 35; < G; alter. of Gk nephrós kidney] * * * Functional unit of the kidney that removes waste and excess substances from the …   Universalium

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