Disodium inosinate

Disodium inosinate
Disodium inosinate
CAS number 4691-65-0  YesY YesY
PubChem 20819
ChemSpider 19594 YesY
Jmol-3D images Image 1
Image 2
Molecular formula C10H11N4Na2O8P
Molar mass 392.17 g/mol
 YesY inosinate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.


Use as a food additive

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.


Disodium inosinate is generally produced from meat or from fish. Alternately, it may be produced from tapioca starch without any animal products involved in the production. Therefore, disodium inosinate may not be suitable for vegans and vegetarians, and in most cases not suitable for observant Jews, Muslims, Hindu and Sikhs, depending on the origin of the product. Like rennet it is normally a non-vegetarian product; only the producer can provide information on the origin although it is in some cases labelled as "vegetarian" in ingredients lists when produced from plant sources.[3]

Toxicology and safety

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[4]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[5] (but it is still mentioned on the last (2009) codex alimentarius list).[6]

See also


  1. ^ PubChem 20819
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". http://www.foodstandards.gov.au/newsroom/publications/choosingtherightstuff/foodadditivesnumeric1680.cfm. Retrieved 1 December 2009. 
  3. ^ http://www.food-info.net/uk/e/e631.htm
  4. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K. C. Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA
  5. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants". ftp://ftp.fao.org/codex/alinorm04/al04_12e.pdf. Retrieved 2 December 2009. 
  6. ^ "Class Names and the International Numbering System for Food Additives". http://www.codexalimentarius.net/web/more_info.jsp?id_sta=7. Retrieved Aug.2010. 

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Look at other dictionaries:

  • disodium inosinate — iˈnōsə̇ˌnāt, īˈ noun Etymology: inosine + ate (I) : a salt C10H11N4Na2O8P that is used chiefly as a flavor enhancer in food …   Useful english dictionary

  • Disodium guanylate — IUPAC name disodium [(2R,3S,4R,5R) 5 (2 amino 6 oxo 3H purin 9 yl) 3,4 dihydroxy 2 …   Wikipedia

  • Disodium ribonucleotides — Disodium inosinate Disodium guany …   Wikipedia

  • Inosinate disodique — Général Nom IUPAC Disodium [(2R,3S,4R,5R) 3,4 dihydroxy 5 (6 hydroxy 9H purin 9 yl)tetrahydrofuran 2 yl]methyl phosphate …   Wikipédia en Français

  • E631 — Disodium inosinate (Miscellaneous » Food) …   Abbreviations dictionary

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