- Antiretroviral drug
Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. When several such drugs, typically three or four, are taken in combination, the approach is known as Highly Active Antiretroviral Therapy, or HAART. The American National Institutes of Health and other organizations recommend offering antiretroviral treatment to all patients with AIDS. Because of the complexity of selecting and following a regimen, the severity of the side-effects and the importance of compliance to prevent viral resistance, such organizations emphasize the importance of involving patients in therapy choices, and recommend analyzing the risks and the potential benefits to patients with low viral loads.
There are different classes of antiretroviral drugs that act on different stages of the HIV life-cycle.
Classes of drugs
Antiretroviral (ARV) drugs are broadly classified by the phase of the retrovirus life-cycle that the drug inhibits.
- Entry inhibitors (or fusion inhibitors) interfere with binding, fusion and entry of HIV-1 to the host cell by blocking one of several targets. Maraviroc and enfuvirtide are the two currently available agents in this class.
- CCR5 receptor antagonists are the first antiretroviral drugs which do not target the virus directly. Instead, they bind to the CCR5 receptor on the surface of the T-Cell and block viral attachment to the cell. Most strains of HIV attach to T-Cells using the CCR5 receptor. If HIV cannot attach to the cell, it cannot gain entry to replicate.
- Nucleoside and nucleotide reverse transcriptase inhibitors (NRTI) inhibit reverse transcription by being incorporated into the newly synthesized viral DNA strand as a faulty nucleotide. This causes a chemical reaction resulting in DNA chain termination.
- Non-nucleoside reverse transcriptase inhibitors (NNRTI) inhibit reverse transcriptase directly by binding to the enzyme and interfering with its function.
- Protease inhibitors (PIs) target viral assembly by inhibiting the activity of protease, an enzyme used by HIV to cleave nascent proteins for the final assembly of new virions.
- Integrase inhibitors inhibit the enzyme integrase, which is responsible for integration of viral DNA into the DNA of the infected cell. There are several integrase inhibitors currently under clinical trial, and raltegravir became the first to receive FDA approval in October 2007.
- Maturation inhibitors inhibit the last step in gag processing in which the viral capsid polyprotein is cleaved, thereby blocking the conversion of the polyprotein into the mature capsid protein (p24). Because these viral particles have a defective core, the virions released consist mainly of non-infectious particles. Alpha interferon is a currently available agent in this class. Two additional inhibitors under investigation are bevirimat  and Vivecon.
AV-HALTs (AntiViral HyperActivation Limiting Therapeutics or 'virostatics') combine immunomodulating and antiviral properties to inhibit a specific antiviral target while also limiting the hyper-elevated state of immune system activation driving disease progression.
The life cycle of HIV can be as short as about 1.5 days from viral entry into a cell, through replication, assembly, and release of additional viruses, to infection of other cells. HIV lacks proofreading enzymes to correct errors made when it converts its RNA into DNA via reverse transcription. Its short life-cycle and high error rate cause the virus to mutate very rapidly, resulting in a high genetic variability of HIV. Most of the mutations either are inferior to the parent virus (often lacking the ability to reproduce at all) or convey no advantage, but some of them have a natural selection superiority to their parent and can enable them to slip past defenses such as the human immune system and antiretroviral drugs. The more active copies of the virus the greater the possibility that one resistant to antiretroviral drugs will be made.
When antiretroviral drugs are used improperly, these multi-drug resistant strains can become the dominant genotypes very rapidly. Improper serial use of the reverse transcriptase inhibitors zidovudine, didanosine, zalcitabine, stavudine, and lamivudine can lead to the development of multi-drug resistant mutations. The mutations can include the V75I, F77L, K103N, F116Y, Q151M, and the M184V mutation. These mutations were observed before protease inhibitors had come into widespread use. The mutants retained sensitivity to the early protease inhibitor saquinavir. These mutants were also sensitive to the rarely used reverse transcriptase inhibitor foscarnet.
Antiretroviral combination therapy defends against resistance by suppressing HIV replication as much as possible.
Combinations of antiretrovirals create multiple obstacles to HIV replication to keep the number of offspring low and reduce the possibility of a superior mutation. If a mutation that conveys resistance to one of the drugs being taken arises, the other drugs continue to suppress reproduction of that mutation. With rare exceptions, no individual antiretroviral drug has been demonstrated to suppress an HIV infection for long; these agents must be taken in combinations in order to have a lasting effect. As a result, the standard of care is to use combinations of antiretroviral drugs. Combinations usually comprise two nucleoside-analogue RTIs and one non-nucleoside-analogue RTI or protease inhibitor. This three drug combination is commonly known as a triple cocktail.
In recent years, drug companies have worked together to combine these complex regimens into simpler formulas, termed fixed-dose combinations. For instance, two pills containing two or three medications each can be taken twice daily. This greatly increases the ease with which they can be taken, which in turn increases adherence, and thus their effectiveness over the long-term. Lack of adherence is a cause of resistance development in medication-experienced patients. Patients who maintain proper therapy can stay on one regimen without developing resistance . This greatly increases life expectancy and leaves more drugs available to the individual should the need arise.
Fixed dose combinations are multiple antiretroviral drugs combined into a single pill.
Brand Name Drug Names (INN) Date of FDA Approval Company Combivir zidovudine + lamivudine September 26, 1997 GlaxoSmithKline Trizivir abacavir + zidovudine + lamivudine November 15, 2000 GlaxoSmithKline Kaletra lopinavir + ritonavir September 15, 2000 Abbott Laboratories Epzicom (in USA)
Kivexa (in Europe)
abacavir + lamivudine August 2, 2004 GlaxoSmithKline Truvada tenofovir/emtricitabine August 2, 2004 Gilead Sciences Atripla efavirenz + tenofovir/emtricitabine July 12, 2006 Gilead Sciences and
The preferred initial regimens in the United States, as of June 2011, are:
- Tenofovir/emtricitabine (a combination of two NRTIs) and efavirenz (a NNRTI). Efavirenz should not be given to pregnant women.
- tenofovir/emtricitabine and raltegravir (an integrase inhibitor)
- tenofovir/emtricitabine, ritonavir and darunavir (both latter are protease inhibitors)
- tenofovir/emtricitabine, ritonavir and atazanavir (both latter are protease inhibitors)
Antiretroviral drug treatment guidelines have changed over time. Prior to 1987, no antiretroviral drugs were available and treatment consisted of treating complications from the immunodeficiency. After antiretroviral medications were introduced, most clinicians agreed that HIV positive patients with low CD4 counts should be treated, but no consensus formed as to whether to treat patients with high CD4 counts.
In 1995, David Ho promoted a "hit hard, hit early" approach with aggressive treatment with multiple antiretrovirals early in the course of the infection. Later reviews noted that this approach of "hit hard, hit early" ran significant risks of increasing side effects and development of multidrug resistance, and this approach was largely abandoned.
The timing of when to initiate therapy has continued to be a core controversy within the medical community. The development of a stable consensus is hampered by the lack of randomized controlled studies with many guidelines and consensus statements basing their recommendations on observational studies. More recently, the trend has been in favor of earlier treatment of asymptomatic HIV patients, with more studies analyzing various treatment regimens in progress.
There is a consensus among experts that, once initiated, antiretroviral therapy should never be stopped. This is because the selection pressure of incomplete suppression of viral replication in the presence of drug therapy causes the more drug sensitive strains to be selectively inhibited. This allows the drug resistant strains to become dominant. This in turn makes it harder to treat the infected individual as well as anyone else they infect.
The current guidelines use new criteria to consider starting HAART, as described below. However, there remain a range of views on this subject and the decision of whether to commence treatment ultimately rests with the patient and their doctor.
The current guidelines for antiretroviral therapy (ART) from the World Health Organization reflect the 2003 changes to the guidelines and recommend that in resource-limited settings (that is, developing nations), HIV-infected adults and adolescents should start ART when HIV infection has been confirmed and one of the following conditions is present :
- Clinically advanced HIV disease;
- WHO Stage IV HIV disease, irrespective of the CD4 cell count;
- WHO Stage III disease with consideration of using CD4 cell counts less than 350/µl to assist decision making;
- WHO Stage I or II HIV disease with CD4 cell counts less than 200/µl.
The treatment guidelines specifically for the USA are set by the United States Department of Health and Human Services (DHHS). The current guidelines for adults and adolescents were stated on December 1, 2009.
• Antiretroviral therapy should be initiated in all patients with a history of an AIDS-defining illness or with a CD4 count <350 cells/mm3 (AI).
• Antiretroviral therapy should also be initiated, regardless of CD4 count, in patients with the following conditions: pregnancy (AI), HIV- associated nephropathy (AII), and hepatitis B virus (HBV) coinfection when treatment of HBV is indicated (AIII).
• Antiretroviral therapy is recommended for patients with CD4 counts between 350 and 500 cells/mm3. The Panel was divided on the strength of this recommendation: 55% voted for strong recommendation (A) and 45% voted for moderate recommendation (B) (A/B-II).
• For patients with CD4 counts >500 cells/mm3, the Panel was evenly divided: 50% favor starting antiretroviral therapy at this stage of HIV disease (B); 50% view initiating therapy at this stage as optional (C) (B/C-III).
• Patients initiating antiretroviral therapy should be willing and able to commit to lifelong treatment and should understand the benefits and risks of therapy and the importance of adherence (AIII). Patients may choose to postpone therapy, and providers, on a case-by-case basis, may elect to defer therapy based on clinical and/or psychosocial factors.
Rating of Recommendations: A = Strong; B = Moderate; C = Optional Rating of Evidence: I = data from randomized controlled trials; II = data from well-designed nonrandomized trials or observational cohort studies with long-term clinical outcomes; III = expert opinion
In countries with a high rate of baseline resistance, resistance testing is recommended prior to starting treatment; or, if the initiation of treatment is urgent, then a "best guess" treatment regimen should be started, which is then modified on the basis of resistance testing. In the UK, there is 11.8% medium to high-level resistance at baseline to the combination of efavirenz + zidovudine + lamivudine, and 6.4% medium to high level resistance to stavudine + lamivudine + nevirapine.
Most current HAART regimens consist of three(3) drugs: 2 NRTIs + a PI/NNRTI/II. Initial regimens use "first-line" drugs with a high efficacy and low side-effect profile.
Treatment guidelines for HIV-1 infected adults in the developed world (that is, those countries with access to all or most therapies and laboratory tests) have been provided by the International AIDS Society-USA(IAS-USA) since 1996. The IAS-USA is a 501(c)(3) not-for-profit organization in the USA (and is not related to the worldwide International AIDS Society or IAS). The IAS-USA guidelines for antiretroviral therapy are developed by a volunteer panel of experts. Its last update was published in August 2008 in the Journal of the American Medical Association. In the 2008 update, the panel recommended that therapy be initiated before the CD4+ cell count declines to below 350/uL and be individualized for the particular patient's situation and comorbidities. For initial therapy, it recommends 2 NRTIs with either an NNRTI, a ritonavir-boosted PI or an integrase inhibitor. In antiretroviral therapy failure, the goal of subsequent treatment is suppression of HIV-1 RNA to below detection; the treatment should ideally have 3 new drugs to which the patient's virus is susceptible. Therapy in selected clinical situations is also described. The IAS-USA also sponsors the development of guidelines for the use of drug resistance testing in patients with HIV-1 infection 
Another set of guidelines (distinct from those of the IAS-USA) are provided by an expert panel convened by the U.S. Department of Health and Human Services. The preferred initial regimens in the United States, as of June 2011, are:
- tenofovir/emtricitabine (a combination of two NRTIs) and efavirenz (a NNRTI). Efavirenz should not be given to pregnant women.
- tenofovir/emtricitabine and raltegravir (an integrase inhibitor)
- tenofovir/emtricitabine, ritonavir and darunavir (both latter are protease inhibitors)
- tenofovir/emtricitabine, ritonavir and atazanavir (both latter are protease inhibitors)
Because HIV disease progression in children is more rapid than in adults, and laboratory parameters are less predictive of risk for disease progression, in particular for young infants, treatment recommendations from the DHHS have been more aggressive in children than in adults; the current guidelines were published November 3, 2005.
HIV Postexposure Prophylaxis (PEP)
In 2005, the Centers for Disease Control and Prevention in the United States recommended a 28-day HIV drug regimen for those that have been exposed to HIV (HIV Postexposure Prophylaxis [PEP]). The WHO recommendations on treatment are that the minimum that should be used is dual NRTIs for 28 days, with triple therapy (dual NRTIs plus a boosted PI) being offered where there is a risk of resistance. The effectiveness of this intervention has never been precisely ascertained, but postexposure prophylaxis is most effective when administered sooner, though not believed to be effective if given 72 hours after exposure.
Prevention of mother-to-child-transmission (PMTCT)
The use of antiretrovirals is also recommended for the prevention of mother-to-child transmission of HIV-1. The current WHO recommended regimen is as follows: where the pregnant woman does not yet need to start ART for therapeutic reasons, she should start Zidovudine (AZT) from 28 weeks or as soon as possible thereafter, be provided with single-dose Nevirapine (NVP) when entering labour, and be given AZT+3TC for one week following delivery. Meanwhile, whether the mother was on the above or standard ART, the child should be given single dose Nevirapine immediately after delivery and daily Zidovudine until one week old. Complementary measures that may also be used include caesarean section and formula feeding; in some settings, the combination of providing all these measures has succeeded in reducing the risk of infection from 25% to about 1%.
There are several concerns about antiretroviral regimens:
- intolerance: The drugs can have serious side-effects, particularly in advanced disease.
- resistance: If patients miss doses, drug resistance can develop,
- cost: Providing anti-retroviral treatment is costly and resource-intensive,[quantify] and the majority of the world's infected individuals cannot access treatment services.
- public health: Individuals who fail to use antiretrovirals properly can develop multi-drug resistant strains which can be passed onto others.
Responses to treatment in older adults
As people age, their bodies are not able to repair and rebuild damaged cells, organs or tissues as rapidly as those of younger people. Diseases like HIV that attack and destroy the body's defenses can exacerbate this slowing and increase the risk of developing additional medical problems like diabetes and high blood pressure, and more physical limitations than younger adults with HIV. In the early years of the HIV epidemic (before HAART), older adults' health deteriorated more rapidly than that of younger individuals - regardless of CD4 count. Several studies found that older adults had lower CD4 counts at diagnosis, faster progression to an AIDS diagnosis, more opportunistic infections, and a shorter survival rate than younger adults, regardless of when they were first diagnosed with HIV.
Recent studies have found that a person's age does not interfere with the ability of HAART to reduce viral load, but there may be differences between younger and older people in how well the immune system responds to treatment. A study published in AIDS (2000) by Roberto Manfredi and Francesco Chiodo examined the effect of HAART on older people (defined as 55 or older) compared to younger people (35 or younger). The study included 21 older people (8 women, 13 men) and 84 younger people (29 women, 55 men). The researchers found that both groups responded to HAART, especially in reducing viral load. However, CD4 counts did not increase as much in the older people relative to the younger ones. On average, CD4 counts increased from 212 to 289 for older adults after one year of HAART. During the same period, CD4 counts rose from 231 to 345 for younger people.
Some people may have a very low CD4 count even though they have an undetectable viral load. This may be related to decreased activity in the thymus (the gland where CD4 cells are made). A 2001 study in AIDS conducted by researchers in Los Angeles included 80 HIV-positive veterans (13 were over 55 and 67 were younger). Although both groups of veterans showed dramatic reductions in viral load once they were on treatment, the researchers found significant differences in CD4 levels at 3, 9, 15, and 18 months. After one year on HAART, average CD4 counts increased by 50 for the older men, compared to increases of 100 for the younger ones. This difference was not related to baseline HIV viral load, coinfection with hepatitis C, or the race/ethnicity of participants. These studies represent an important first step in understanding how their age may affect older adults' response to HIV treatment, but more studies are needed to understand the long-term effects of age on HAART in older adults.
If an HIV infection becomes resistant to standard HAART, there are limited options. One option is to take larger combinations of antiretroviral drugs, an approach known as mega-HAART or salvage therapy. Salvage therapy often increases the drugs' side-effects.
If an HIV infection becomes sufficiently resistant to antiretroviral-drugs, treatment becomes more complicated and prognosis may deteriorate. Treatment options continue to improve as additional new drugs enter clinical trials. However, the limited distribution of many such drugs denies their benefits to patients, particularly in the developing world.
Structured treatment interruptions
Drug holidays (or "structured treatment interruptions"), are intentional discontinuations of antiretroviral drug treatment.
Intermittent therapy was an experimental approach designed to reduce exposure to antiretroviral drugs in an effort to mitigate side-effects. Intermittent therapy differed from treatment interruptions in that it involved using a much shorter cycle of switching on and off the antiviral drugs. Studies of such approaches include schedules of week-on, week-off (also known as "wowo") and five-days-on, two-days-off (also known as "foto"), which skipped treatment on weekends. Intermittent therapy is ineffective and results in drug resistance.
Suppressing HIV is inadequate to restore normal immune function. HIV can damage the ability of the thymus to produce normally diverse T-cells. Also, rapid suppression of HIV and partial restoration of the immune system sometimes produces a dangerous hypersensitivity reaction, immune reconstitution inflammatory syndrome. Research continues in these areas.
With the exception of post exposure prophylaxis, current treatment guidelines do not call for the interruption of drug therapy once it has been initiated.
Adverse effects of antiretroviral drugs vary by drug, by ethnicity, by individual, and by interaction with other drugs, including alcohol. Hypersensitivity to some drugs may also occur in some individuals. The following list is not complete, but includes several of the adverse effects experienced by patients taking some antiretroviral drugs:
- Abdominal pain (Ritonavir)
- Alopecia (INF-alpha)
- Anemia (AZT)
- Diarrhea (Abacavir)
- Dizziness (Vertigo)
- Fanconi syndrome
- Flatulence (Tenofovir)
- Headache (3TC overdose)
- Hyperpigmentation (Emtricitabine)
- Ingrown nails (IDV)
- Insomnia (Emtricitabine)
- Lipodystrophy / HIV-associated lipodystrophy
- Liver failure
- Mental confusion (EVZ)
- Mitochondrial toxicity (ddI > d4T > AZT)
- Mood swings
- Myalgia (AZT overdose)
- Myopathy (AZT overdose)
- Nausea (AZT)
- Neutropenia (AZT)
- Nightmares (EFZ)
- Oral ulcers (ddC)
- Pancreatitis (ddI)
- Paresthesia (IDV)
- Peripheral neuropathy (ddI, ddC, d4T)
- Renal failure or insufficiency (IDV, TDF)
- Somnolence (drowsiness)
- Stevens-Johnson syndrome
- Change in taste perception
- Vomiting (AZT)
- Xeroderma (dry skin)
- Xerostomia (dry mouth)
- Antiviral drug
- Discovery and Development of HIV Protease Inhibitors
- Discovery and Development of Non-Nucleoside Reverse Transcriptase Inhibitors
- Discovery and development of nucleoside and nucleotide reverse transcriptase inhibitors
- ^ a b Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK; Panel on Clinical Practices for Treatment of HIV (September 2002). "Guidelines for using antiretroviral agents among HIV-infected adults and adolescents". Ann. Intern. Med. 137 (5 Pt 2): 381–433. PMID 12617573.
- ^ Barr SD, Smiley JR, Bushman FD (February 2008). Hope, Thomas J.. ed. "The interferon response inhibits HIV particle production by induction of TRIM22". PLoS Pathog. 4 (2): e1000007. doi:10.1371/journal.ppat.1000007. PMC 2279259. PMID 18389079. http://dx.plos.org/10.1371/journal.ppat.1000007.
- ^ Panacos Pharmaceuticals. "Clinical Trial: Phase 2 Safety and Efficacy Study of Bevirimat Functional Monotherapy in HIV Treatment-Experienced Patients for 2 Weeks*". ClinicalTrials.gov. http://clinicaltrials.gov/ct/show/NCT00511368. Retrieved 2007-08-28.
- ^ Lori, F.; Foli, A.; Groff, A.; Lova, L.; Whitman, L.; Bakare, N.; Pollard, R.; Lisziewicz, J. (2005). "Optimal suppression of HIV replication by low-dose hydroxyurea through the combination of antiviral and cytostatic ('virostatic') mechanisms". AIDS (London, England) 19 (11): 1173–1181. PMID 15990570.
- ^ Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD (1996). "HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time". Science 271 (5255): 1582–6. doi:10.1126/science.271.5255.1582. PMID 8599114.
- ^ Schmit, JC; Cogniaux, J; Hermans, P; Van Vaeck, C; Sprecher, S; Van Remoortel, B; Witvrouw, M; Balzarini, J et al. (1996). "Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain.". The Journal of infectious diseases 174 (5): 962–8. doi:10.1093/infdis/174.5.962. PMID 8896496.
- ^ United States Department of Health and Human Services (2004). "A Guide to Primary Care for People With HIV/AIDS, 2004 Edition" (PDF). ftp://ftp.hrsa.gov/hab/PCGchap5.pdf. Retrieved 2006-07-03.
- ^ Attacking AIDS with a 'Cocktail' Therapy
- ^ AIDS Education Online (2005). "HIV Medication Education, copyright 2004" (Plain text). http://www.aidsdrugsonline.com/index.php?option=com_content&view=article&id=50&Itemid=27. Retrieved 2008.
- ^ http://www.edinformatics.com/biotechnology/antiretroviral_drugs.htm
- ^ a b c d Department of Health and Human Services (December 2009). "HIV and Its Treatment: What You Should Know" (PDF). http://aidsinfo.nih.gov/ContentFiles/HIVandItsTreatment_cbrochure_en.pdf. Retrieved 2006-11-04. Reviewed June 2011
- ^ Darbyshire, J. (1995). "Perspectives in drug therapy of HIV infection". Drugs 49 Suppl 1: 1–3; discussion 38–40. PMID 7614897.
- ^ Ho, D. (1995). "Time to hit HIV, early and hard". The New England journal of medicine 333 (7): 450–451. doi:10.1056/NEJM199508173330710. PMID 7616996.
- ^ Harrington, M.; Carpenter, C. C. (2000). "Hit HIV-1 hard, but only when necessary". The Lancet 355 (9221): 2147. doi:10.1016/S0140-6736(00)02388-6.
- ^ Jain V, Deeks SG (May 2010). "When to start antiretroviral therapy". Curr HIV/AIDS Rep 7 (2): 60–8. doi:10.1007/s11904-010-0044-6. PMC 2856854. PMID 20425559. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2856854.
- ^ a b c Panel on Antiretroviral Guidelines for Adults and Adolescents (2009-12-01). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. United States Department of Health and Human Services. p. i. http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Retrieved 2010-10-12.
- ^ World Health Organization (2003). "Scaling up retroviral therapy in resource limited settings" (PDF). http://www.who.int/hiv/pub/prev_care/en/arvrevision2003en.pdf. Retrieved 2006-01-17.
- ^ UK Group of Transmitted HIV Drug Resistance (2005). "Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study". Brit Med J 331 (7529): 1368–71. doi:10.1136/bmj.38665.534595.55. PMC 1309643. PMID 16299012. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1309643.
- ^ Hammer, Eron, Reiss, et al. JAMA 2008; 300:555-570
- ^ Hirsch MS, Gunthard HF, Schapiro, et al. Clin Infect Dis 2008; 47: 266-285
- ^ Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children (November 3, 2005). "Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection" (PDF). Department of Health and Human Services. http://www.aidsinfo.nih.gov/ContentFiles/PediatricGuidelines_PDA.pdf. Retrieved 2006-01-17.
- ^ Smith DK, Grohskopf LA, Black RJ, et al. (January 2005). "Antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the U.S. Department of Health and Human Services". MMWR Recomm Rep 54 (RR-2): 1–20. PMID 15660015. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5402a1.htm.
- ^ a b http://www.who.int/entity/hiv/pub/guidelines/PEP/en/index.html
- ^ http://www.who.int/entity/hiv/pub/guidelines/pmtctguidelines3.pdf
- ^ Coovadia H (July 2004). "Antiretroviral agents--how best to protect infants from HIV and save their mothers from AIDS". N. Engl. J. Med. 351 (3): 289–92. doi:10.1056/NEJMe048128. PMID 15247337.
- ^ Saitoh A, Hull AD, Franklin P, Spector SA (August 2005). "Myelomeningocele in an infant with intrauterine exposure to efavirenz". J Perinatol 25 (8): 555–6. doi:10.1038/sj.jp.7211343. PMID 16047034.
- ^ Groopman, JE (1990). "Zidovudine intolerance.". Reviews of infectious diseases 12 Suppl 5: S500–6. PMID 2201071.
- ^ Beardsley T (July 1998). "Coping with HIV's ethical dilemmas". Scientific American 279 (1): 106–7. doi:10.1038/scientificamerican0798-106. PMID 9648307.
- Cohen, Mardge H., MD, et al., "Medically Eligible Women Who Do Not Use HAART: The Importance of Abuse, Drug Use, and Race", American Journal of Public Health, Vol 94, No. 7, July 2004, pp. 1147–1151. American Public Health Association
- Cohen, Mardge H., MD, et al., "Impact of Highly Active Antiretroviral Therapy on Anemia and Relationship Between Anemia and Survival in a Large Cohort of HIV-Infected Women: Women's Interagency HIV Study", Medscape CME, 11/17/2004
- AIDSinfo - Comprehensive resource for HIV/AIDS treatment and clinical trial information from the U. S. Department of Health and Human Services
- Origins of antiretroviral combination therapy
- Viral Load research papers, including effectiveness of HAART on reducing viral load
- Current status of gene therapy strategies to treat HIV/AIDS
Antiviral drugs: antiretroviral drugs used against HIV (primarily J05) Entry/fusion inhibitors
(Discovery & development)
Nucleoside analogues/NARTIs: Abacavir (ABC)°# • Emtricitabine (FTC)°# • Lamivudine (3TC)°# • Didanosine (ddI)# • Zidovudine (AZT)# • Apricitabine† • Stampidine† • Elvucitabine† • Racivir† • Amdoxovir†• Stavudine (d4T)# • Zalcitabine (ddC)◊ • Festinavir†Nucleotide analogues/NtRTIs: Tenofovir°# • GS 7340Non-Nucleoside (NNRTI)
(Discovery & development)
Integrase inhibitors Maturation inhibitors Protease Inhibitors (PI)
(Discovery and development)1st generation2nd generation
Combined formulations Experimental agentsTRIM5alpha (gene)Tat antagonistsTrichosanthinOtherAbzyme • Calanolide A • Ceragenin • Cyanovirin-N • Diarylpyrimidines • Epigallocatechin gallate (EGCG) • Foscarnet • Griffithsin • Hydroxycarbamide • Miltefosine • Portmanteau inhibitors • Seliciclib† • Synergistic enhancers • Tre recombinase • Zinc finger protein transcription factor • KP-1461† • Cobicistat†Failed agents#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III °DHHS preferred first-line agent. ◊Formerly or rarely used agent.
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