- Genetic variability
Genetic variability is a measure of the tendency of individual genotypes in a
populationto vary from one another. Variability is different from genetic diversity, which is the amount of variation seen in a particular population. cite book| title=Variation and Variability| year=1995| publisher=Yale University| accessdate=2007-05-24| url=http://www.cbc.yale.edu/old/cce/papers/ALife/node2.html ] The variability of a trait describes how much that trait tends to vary in response to environmental and genetic influences. Genetic variability in a population is important for biodiversity, because without variability, it becomes difficult for a population to adapt to environmental changes and therefore makes it more prone to extinction. Variability is an important factor in evolutionas it affects an individual's response to environmental stress and thus can lead to differential survival of organisms within a population due to natural selectionof the most fit variants. Genetic variability also underlies the differential susceptibility of organisms to diseases and sensitivity to toxins or drugs — a fact that has driven increased interest in personalized medicinegiven the rise of the human genome projectand efforts to map the extent of human genetic variation such as the HapMap project.
Causes of Variability
There are many sources of genetic variability in a population:
recombinationis one source of variability; during meiosisin sexual creatures two homologous chromosomesfrom the male and the female cross over one another and exchange gene sequences. The chromosomes then split apart and are ready to form an offspring. The cross-over is random and is governed by its own set of genes that code for where crossovers can occur (in cis) and for the mechanism behind the exchange of DNAchunks (in trans). Being controlled by genes means that recombination is also variable in frequency, location, thus it can be selected to increase fitness by nature, because the more recombination the more variability and the more variability the easier it is for the population to handle changes. [ cite journal| author=Burt, Austin| title=Perspective: Sex, Recombination, and the Efficacy of Selection—Was Weismann Right?| journal=Evolution: International Journal of Organic Evolution| issue=54.2 |year=2000| pages=337–351 ]
Immigration, emigration, and translocation– each of these is the movement of an individual into or out of a population. When an individual comes from a previously genetically isolated population into a new one it will increase the genetic variability of the next generation if it reproduces. cite journal| author=Ehrich, Dorothy and Per Erik Jorde| title=High Genetic Variability Despite High-Amplitude Population Cycles in Lemmings| journal=Journal of Mammalogy| issue=86.2| year=2005| pages=380–385| doi=10.1644/BER-126.1| volume=86 ]
Polyploidy– having more than two homologous chromosomes allows for even more recombination during meiosis allowing for even more genetic variability in one's offspring.
*Diffuse centromeres – in
asexualorganisms where the offspring is an exact genetic copy of the parent, there are limited sources of genetic variability. One thing that increased variability, however, is having diffused instead of localized centromeres. Being diffused allows the chromatidsto split apart in many different ways allowing for chromosome fragmentation and polyploidy creating more variability. cite journal| author=Linhart, Yan and Janet Gehring| title=Genetic Variability and its Ecological Implications in the Clonal Plant Carex scopulurum Holm. In Colorado Tundra| journal=Arctic, Antarctic and Alpine Research| issue=35.4 |year=2003| pages=429–433| doi=10.1657/1523-0430(2003)035 [0429:GVAIEI] 2.0.CO;2| volume=35 ]
mutations– contribute to the genetic variability within a population and can have positive, negative, or neutral effects on an fitness. cite book| author=Wills, Christopher| title=Genetic Variability| publisher=NewYork: Oxford University Press| year=1980 ] This variability can be easily propagated throughout a population by natural selectionif the mutation increases the affected individual's fitness and its effects will be minimized/hidden if the mutation is deleterious. However, the smaller a population and its genetic variability are, the more likely the recessive/hidden deleterious mutations will show up causing genetic drift.
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