Gallbladder


Gallbladder
Gallbladder
Illu pancrease.svg
Diagram of Stomach
Surface projections of the organs of the trunk.png
Surface projections of the organs of the trunk, with gallbladder labeled at the transpyloric plane.
Latin vesica fellea; vesica biliaris
Gray's subject #250 1197
System Digestive system (GI Tract)
Artery Cystic artery
Vein Cystic vein
Nerve Celiac ganglia, vagus[1]
Precursor Foregut
1. Bile ducts: 2. Intrahepatic bile ducts, 3. Left and right hepatic ducts, 4. Common hepatic duct, 5. Cystic duct, 6. Common bile duct, 7. Ampulla of Vater, 8. Major duodenal papilla
9. Gallbladder, 10-11. Right and left lobes of liver. 12. Spleen.
13. Esophagus. 14. Stomach. Small intestine: 15. Duodenum, 16. Jejunum
17. Pancreas: 18: Accessory pancreatic duct, 19: Pancreatic duct.
20-21: Right and left kidneys (silhouette).
The anterior border of the liver is lifted upwards (brown arrow). Gallbladder with Longitudinal section, pancreas and duodenum with frontal one. Intrahepatic ducts and stomach in transparency.

In vertebrates the gallbladder (cholecyst, gall bladder, Biliary Vesicle) is a small organ that aids mainly in fat digestion and concentrates bile produced by the liver. In humans the loss of the gallbladder is usually easily tolerated.

Contents

Human anatomy

The gallbladder is a hollow system that sits just beneath the liver.[2] In adults, the gallbladder measures approximately 8 centimetres (3.1 in) in length and 4 centimetres (1.6 in) in diameter when fully distended.[3] It is divided into three sections: fundus, body and neck. The neck tapers and connects to the biliary tree via the cystic duct, which then joins the common hepatic duct to become the common bile duct. At the neck of the gall bladder is a mucosal fold called Hartmann's pouch, where gallstones commonly get stuck. The angle of the gallbladder is located between the costal margin and the lateral margin of the rectus abdominis muscle.

Microscopic anatomy

Micrograph of a normal gallbladder wall. H&E stain.

The different layers of the gallbladder are as follows:[4]

  • The epithelium, a thin sheet of cells closest to the inside of the gallbladder
  • The lamina propria, a thin layer of loose connective tissue (the epithelium plus the lamina propria form the mucosa)
  • The muscularis, a layer of smooth muscular tissue that helps the gallbladder contract, squirting its bile into the bile duct
  • The perimuscular ("around the muscle") fibrous tissue, another layer of connective tissue
  • The serosa, the outer covering of the gallbladder that comes from the peritoneum, which is the lining of the abdominal cavity

Unlike elsewhere in the intestinal tract, the gallbladder does not have a muscularis mucosae.

Function

When food containing fat enters the digestive tract, it stimulates the secretion of cholecystokinin (CCK). In response to CCK, the adult human gallbladder, which stores about 50 millilitres (1.7 U.S. fl oz; 1.8 imp fl oz) of bile, releases its contents into the duodenum. The bile, originally produced in the liver, emulsifies fats in partly digested food.

During storage in the gallbladder, bile becomes more concentrated which increases its potency and intensifies its effect on fats.

In 2009, it was demonstrated that the gallbladder removed from a patient expressed several pancreatic hormones including insulin.[5] This was surprising because until then, it was thought that insulin was only produced in pancreatic β-cells. This study provides evidence that β-like cells do occur outside the human pancreas. The authors suggest that since the gallbladder and pancreas are adjacent to each other during embryonic development, there exists tremendous potential in derivation of endocrine pancreatic progenitor cells from human gallbladders that are available after cholecystectomy.

In animals

Most vertebrates have gallbladders, whereas invertebrates do not. However, its precise form and the arrangement of the bile ducts may vary considerably. In many species, for example, there are several separate ducts running to the intestine, rather than a single common bile duct, as in humans. Several species of mammals (including horses, deer, rats, and various lamoids[6]) and several species of birds lack a gallbladder altogether, as do lampreys.[7]

See also

References

  1. ^ Ginsburg, Ph.D., J.N. (2005-08-22). "Control of Gastrointestinal Function". In Thomas M. Nosek, Ph.D.. Gastrointestinal Physiology. Essentials of Human Physiology. Augusta, Georgia, United State: Medical College of Georgia. pp. p. 30. http://www.lib.mcg.edu/edu/eshuphysio/program/section6/6ch2/6ch2line.htm. Retrieved 2007-06-29. 
  2. ^ http://www.buzzle.com/articles/where-is-the-gallbladder-located-in-the-body.html
  3. ^ Jon W. Meilstrup (1994). Imaging Atlas of the Normal Gallbladder and Its Variants. Boca Raton: CRC Press. pp. 4. ISBN 0-8493-4788-2. 
  4. ^ "Staging of Gallbladder Cancer". http://www.cancer.org/Cancer/GallbladderCancer/DetailedGuide/gallbladder-staging. 
  5. ^ Sahu S, Joglekar MV, Dumbre R, Phadnis SM, Tosh D, Hardikar AA. (2009) Islet-like cell clusters occur naturally in human gall bladder and are retained in diabetic conditions. J Cell Mol Med. 2009 May;13(5):999-1000
  6. ^ C. Michael Hogan. 2008. Guanaco: Lama guanicoe, GlobalTwitcher.com, ed. N. Strömberg
  7. ^ Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. p. 355. ISBN 0-03-910284-X. 

External links


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Look at other dictionaries:

  • gallbladder — [gôl′blad΄ər] n. a membranous sac closely connected by various ducts to the liver, in which excess gall, or bile, is stored and concentrated …   English World dictionary

  • gallbladder — /gawl blad euhr/, n. Anat. a pear shaped, muscular sac attached to the undersurface of the right lobe of the liver, in which bile is stored and concentrated. Also, gall bladder. [1670 80; GALL1 + BLADDER] * * * Muscular membranous sac under the… …   Universalium

  • gallbladder — The pear shaped organ found below the liver. Bile is concentrated and stored in the gallbladder …   English dictionary of cancer terms

  • gallbladder — noun Date: 1676 a membranous muscular sac in which bile from the liver is stored …   New Collegiate Dictionary

  • gallbladder — A pear shaped receptacle on the inferior surface of the liver, in a hollow between the right lobe and the quadrate lobe; it serves as a storage reservoir for bile. SYN: vesica biliaris [TA], vesica fellea, bile cyst, cholecyst …   Medical dictionary

  • gallbladder — n. sac attached to the liver in which bile is stored …   English contemporary dictionary

  • gallbladder — gall′blad der or gall′ blad der n. anat. a membranous sac attached by ducts to the liver, in which bile is stored and concentrated • Etymology: 1670–80 …   From formal English to slang

  • gallbladder — noun a muscular sac attached to the liver that stores bile (secreted by the liver) until it is needed for digestion (Freq. 1) • Syn: ↑gall bladder • Hypernyms: ↑bladder, ↑vesica • Part Holonyms: ↑thorax, ↑ …   Useful english dictionary

  • Gallbladder polyp — Gallbladder Polyps are growths or lesions resembling growths (polypoid lesions) in the wall of the gallbladder. True polyps are abnormal accumulations of mucous membrane tissue that would normally be shed by the body. The main types of polypoid… …   Wikipedia

  • Gallbladder cancer — ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D005706 Gallbladder cancer is a relatively uncommon cancer. If it is diagnosed early enough, it can be cured by removing the gallbladder. Most often it is found after symptoms… …   Wikipedia


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