- Vertigo (medical)
Name = PAGENAME
ICD9 = ICD9|438.85
eMedicineSubj = neuro
Vertigo (from the
Latin"vertere", to turn, and the suffix "-igo", a condition, i. e., "a condition of turning about" [cite web |url=http://www.m-w.com/dictionary/vertigo |title=Definition of vertigo - Merriam-Webster Online Dictionary |accessdate=2007-09-19 |format= |work=] ) is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings.
There are two types of vertigo: subjective and objective. There is a "subjective" vertigo when a person has a false sensation of movement. In the case of "objective vertigo", the surroundings appear to move past a person's field of vision.
The effects of vertigo may be slight. It can cause
nauseaand vomitingand, in severe cases, it may give rise to difficulties with standing and walking.
Vertigo is usually associated with a problem in the
inner earbalance mechanisms ( vestibular system), in the brain, or with the nerve connections between these two organs.
Vertigo can be a symptom of an inner ear infection or of an underlying harmless cause. The most common cause of Vertigo is
benign paroxysmal positional vertigo, or BPPV; however, vertigo can indicate the existence of more serious problems, including drug toxicities (specifically gentamicin), strokes or tumors(though these are much less common than BPPV), and syphilis.
Vertigo can also be a symptom of
multiple sclerosis(MS). People with MS can feel off balance or lightheaded.
Vertigo can also be brought on suddenly through various actions or incidents, such as skull fractures or
brain trauma, sudden changes of blood pressure, or as a symptom of motion sickness while sailing, riding amusement rides, aeroplanes or in a motor vehicle. Vertigo can also be caused by carbon monoxide poisoning. It is also one of the more common symptoms of superior canal dehiscence syndromeand Meniere's disease.
Vertigo-like symptoms may also appear as
paraneoplastic syndrome(PNS) in the form of opsoclonus myoclonus syndrome, a multi-faceted neurological disorder associated with many forms of incipient cancer lesions or viruses.
Vertigo is typically classified into one of two categories depending on the location of the damaged vestibular pathway. These are peripheral or central vertigo. Each category has a distinct set of characteristics and associated findings.
Vertigo can also occur after long flights or boat journeys where the mind gets used to turbulence, resulting in a person's feeling as if he is moving up and down. This usually subsides after a few days.
There is also documented evidence that
Genital Wartscan cause it.Fact|date=October 2008
The neurochemistry of vertigo includes 6 primary
neurotransmitters that have been identified between the 3-neuron arc that drives the vestibulo-ocular reflex(VOR). Many others play more minor roles.
Three neurotransmitters that work peripherally and centrally include
glutamate, acetylcholine, and GABA.
Glutamate maintains the resting discharge of the central vestibular neurons, and may modulate synaptic transmission in all 3 neurons of the VOR arc. Acetylcholine appears to function as an excitatory neurotransmitter in both the peripheral and central synapses. GABA is thought to be inhibitory for the commissures of the medial vestibular nucleus, the connections between the cerebellar
Purkinje cellsand the lateral vestibular nucleus, and the vertical VOR.
Three other neurotransmitters work centrally.
Dopaminemay accelerate vestibular compensation. Norepinephrinemodulates the intensity of central reactions to vestibular stimulation and facilitates compensation. Histamineis present only centrally, but its role is unclear. It is known that centrally acting antihistamines modulate the symptoms of motion sickness.
The neurochemistry of
emesisoverlaps with the neurochemistry of motion sickness and vertigo. Acetylcholine, histamine, and dopamine are excitatory neurotransmitters, working centrally on the control of emesis. GABA inhibits central emesis reflexes. Serotoninis involved in central and peripheral control of emesis but has little influence on vertigo and motion sickness.
vestibular system(balance) function include electronystagmography(ENG), rotation tests, Caloric reflex test, [cite web |url=http://www.bcm.edu/oto/studs/vertigo.html |title=Core Curriculum: Inner Ear Disease - Vertigo |accessdate=2007-09-19 |format= |work=] and Computerized Dynamic Posturography (CDP). Tests of auditory system(hearing) function include pure-tone audiometry, speech audiometry, acoustic-reflex, electrocochleography (ECoG), otoacoustic emissions (OAE), and auditory brainstem response test (ABR; also known as BER, BSER, or BAER). Other diagnostic tests include magnetic resonance imaging(MRI) and computerized axial tomography(CAT or CT).
Treatment is specific for underlying disorder of vertigo:
*calcium channel antagonists, specifically
GABAmodulators, specifically gabapentinand baclofen
*neurotransmitter reuptake inhibitors such as SSRI's, SNRI's and
benign paroxysmal positional vertigo( BPPV), a special kind of vertigo, is treated with the Epley maneuver(performed by a doctor or physical therapist, or with a BPPV maneuver at home)
* [http://www.undiag.com/symptoms/vertigo.php Vertigo information]
* [http://www.vertigocure.org Vertigo Information - Causes, Symptoms, Treatment]
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