Von Hippel-Lindau binding protein 1


Von Hippel-Lindau binding protein 1

protein
Name=von Hippel-Lindau binding protein 1
caption=


width=
HGNCid=12662
Symbol=VBP1
AltSymbols=
EntrezGene=7411
OMIM=300133
RefSeq=NM_003372
UniProt=P61758
PDB=
ECnumber=
Chromosome=X
Arm=q
Band=28
LocusSupplementaryData=

von Hippel-Lindau–binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel-Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. [cite journal | author = Tsuchiya H, Iseda T and Hino O | title = Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product | journal = Cancer Research | volume = 56 | year = 1996 | pages = 2881–5 | pmid = 8674032] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.cite web | title = GenAtlas report: VBP1 | url = http://www.dsi.univ-paris5.fr/genatlas/fiche.php?symbol=VBP1 | date = 2003-01-17 | accessdate = 2007-07-17]

VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits, and is a member of the prefoldin-α subunit family.cite web | title = NiceProt report: P61758 (Prefoldin 3, human) | url = http://www.expasy.org/cgi-bin/niceprot.pl?P61758 | date = 2007-07-10 | accessdate = 2007-07-17] It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm. The VBP1 gene is located at Xq28. [cite journal | author = Brinke A, Green PM and Giannelli F | title = Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue | journal = Genomics | volume = 45 | pages = 105–12 | year = 1997 | pmid = 9339366 | doi = 10.1006/geno.1997.4902] Homologues are known to exist between human VBP1 and proteins in mice, "Drosophila" and "C. elegans".

ee also

*von Hippel-Lindau tumor suppressor
*von Hippel-Lindau disease
*Eugen von Hippel
*Arvid Lindau

References

External links

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