p21 activated kinases

p21 activated kinases

p21 activated kinases (PAKs) are members of a family of enzymes.[1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

  • PAK1, regulating cell motility and morphology[2]
  • PAK2, possibly playing a role in apoptosis[3]
  • PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity[4]
  • PAK4, a mediator of filopodia formation[5]

References

External links