Polyuridylation

Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage.^[1]

References

1. ^ Wilusz CJ, Wilusz J (2008). "New ways to meet your (3') end oligouridylation as a step on the path to destruction". Genes Dev. 22 (1): 1–7. doi:10.1101/gad.1634508. PMC 2731568. PMID 18172159. http://genesdev.cshlp.org/content/22/1/1.long. 

This molecular biology article is a stub. You can help Wikipedia by expanding it.v · Categories: RNA Molecular and cellular biology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Oligo Oligoasthenozoospermia Look at other dictionaries: RNA splicing — In molecular biology and genetics, splicing is a modification of an RNA after transcription, in which introns are removed and exons are joined. This is needed for the typical eukaryotic messenger RNA before it can be used to produce a correct… …   Wikipedia Alternative splicing — produces two protein isoforms. Alternative splicing (or differential splicing) is a process by which the exons of the RNA produced by transcription of a gene (a primary gene transcript or pre mRNA) are reconnected in multiple ways during RNA… …   Wikipedia Polyadenylation — Typical structure of a mature eukaryotic mRNA Polyadenylation is the addition of a poly(A) tail to an RNA molecule. The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases …   Wikipedia Cleavage and polyadenylation specificity factor — (CPSF) (or Cleavage polyadenylation stimulating factor) is involved in the cleavage of the 3 signaling region from a newly synthesized pre messenger RNA (pre mRNA) molecule in the process of gene transcription. It is the first protein to bind to… …   Wikipedia Cleavage stimulation factor — Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric protein of about 200 kilodaltons that is involved in the cleavage of the 3 signaling region from a newly synthesized pre messenger RNA (mRNA) molecule.… …   Wikipedia PABPN1 — Poly(A) binding protein, nuclear 1 Rendering based on PDB 3B4D …   Wikipedia DCP2 — decapping enzyme homolog (S. cerevisiae) Identifiers Symbols DCP2; FLJ33245; NUDT20 External IDs …   Wikipedia DCP1A — DCP1 decapping enzyme homolog A (S. cerevisiae) Identifiers Symbols DCP1A; FLJ21691; HSA275986; Nbla00360; SMAD4IP1; SMIF External IDs …   Wikipedia DCP1B — DCP1 decapping enzyme homolog B (S. cerevisiae) Identifiers Symbols DCP1B; DCP1; hDcp1b External IDs …   Wikipedia Messenger RNA decapping — The process of messenger RNA decapping consists of hydrolysis of the 5 cap structure on the RNA exposing a 5 monophosphate. This 5 monophosphate is a substrate for the exonuclease Xrn1 and the message is quickly destroyed. There are many… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”