Notopterygium incisum

Notopterygium incisum
Scientific classification
Kingdom:	Plantae
(unranked):	Angiosperms
(unranked):	Eudicots
Order:	Apiales
Family:	Apiaceae
Genus:	Notopterygium
Species:	N. incisum
Binomial name
Notopterygium incisum Ting ex H. T. Chang

The Notopterygium Root, Notopterygium incisum, is perennial herb native to east asia. Its root and rhizome parts of the plant have long been used for their medicinal properties, and the plant continues to be thoroughly studied to this day. As a result of its numerous beneficial and healing qualities, it has become endangered due to excessive cultivation as a commercial product.

Distribution

Notopterygium incisum grows naturally in the provinces of Gansu, Qinghai, Shaanxi, Sichuan, and Xizang, China.^[1] It is predominantly found on several mountains and counties including, Duzhe mountain of Kangding County, and Goaoershi mountain of Yajiang county, and the Litangjunba, Daofu, Luhuo, Seda, Ganzi, and north-central region of Schicu county.^[2] Much of the native population is at risk from overharvesting, fragmentation, and environmental degredation, however new harvesting efforts are being assessed (in these same Provinces) in order to protect the species. Studies show that the species has the best chance for sustainability in the provinces which it has previously grown naturally.^[3]

Habitat and Ecology

The perennial “Notopterygium incisum” grows at a range of 1600 to 5000 meters above sea level.^[1] It lives among forest edges and scrubs that border the grasslands of these elevated slopes.^[2] In a controlled study, the most preferred soil habitat for seedling germination was at 15 degrees Celsius, in a loosely packed medium with high organic content.^[4] While this was in an incubated setting, it is generally acceptable to assume that natural conditions are at least somewhat similar.

Morphology

incisum

Individuals of this species are herbaceous and are rhizomatic. The aromatic, clustered roots are dark brown and often have node scarring.^[1] The rhizome portion which grows as a horizontal stem underground gives rise to new roots, and also shoots which eventually produce stems and then flowers.^[5] The leaves are ternate-3-pinnate with calyx teeth and petioles about 5–12 cm long. The shoots can have anywhere from 3-6 linear bracts about 1–3 cm long. The flowers are located in crowded, umbellules.^[1]

Flowers and Fruit

incisum Flower Flowers of “Notopterygium incisum”, as mentioned above are located in very dense umbellues and can be described as “many flowered." ^[1] The petals are white/greenish-white, in ovate/oblong-ovate shape that are 1.5 by 1mm in size. They are arranged apex obtuse and are inflexed. The fruits are oblong-ellipsoid shaped shaped and range from 5-6 by 2.5-3.5mm in size. Flowering takes place from July to August while fruits follow in the months of August to September.^[1]

Medicinal Usage

Notopterygium Roots The plant has numerous medical uses, yet its main use is in the traditional Chinese medicine “qiang huo.” The roots and rhizome of the plant are used in herbal preparations for a series of symptoms from the common cold, chills, fever, rheumatoid arthritis, and general limb or body aches and pains.^[5] While the root was traditionally used as an herbal remedy, the root is being more closely studied for its detailed content and other potential uses. In a study of both the roots and rhizome, it was found that they have a total of 24 different compounds.^[6] The most notable compounds include:

• Furocoumarins such as notopterol which have anti-proliferative (anti-cell growth), and apoptotic (cell death) effects on certain cancer cells.^[7]

• Falcarindiol which induces expression of antioxidant enzymes.^[8]

• Phenethyl ferulate, which is similar to anti-inflammatory medications as a COX inflammatory pathway inhibitor (inhibits inflammatory response of the nervous system associated with pain and swelling).^[9]

References

1. ^ ^{a b c d e f} Notopterygium incisum. Flora of China. Retrieved June 20, 2011, from http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=200015680
2. ^ ^{a b} (2010, February 07). Investigation of Notopterygium Spp-Resources of Medicinal Plants in Ganzi Region, Sichuan Province, and Research on Its Photosynthetic Characteristics. China Papers. Retrieved June 25, 2011, from http://mt.china-papers.com/1/?p=148935
3. ^ Sun H; Jiang S; Chen S; Zhou Y; Xie C; Ma X; Chen T.Studies on habitats suitability of endangered medicinal plant Notopterygium incisum. China Journal Of Chinese Materia Medica. 2009 Mar.Vol.34,Iss.5;p.535-8 Source: MEDLINE (EBSCOhost) (http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=mnh) Link to content: http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?direct=true&db=mnh&site=ehost-live&AN=19526777 More full text options: http://an5qy7ag4q.search.serialssolutions.com.libproxy.cc.stonybrook.edu?sid=CentralSearch:null&genre=article&atitle=%5BStudies+on+habitats+suitability+of+endangered+medicinal+plant+Notopterygium+incisum%5D.&volume=34&issue=5&title=Zhongguo+Zhong+Yao+Za+Zhi+%3D+Zhongguo+Zhongyao+Zazhi+%3D+China+Journal+Of+Chinese+Materia+Medica&issn=1001-5302&date=2009-03-01&spage=535&aulast=Sun&aufirst=H
4. ^ Shi J; Jiang SY; Ma XJ; Sun H; Zhou Y. Studies on seeds germination and seedlings growth of Notopterygium incisum. China Journal Of Chinese Materia Medica. 2007 Sep.Vol.32,Iss.18;p.1841-4 Source: MEDLINE (EBSCOhost) (http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=mnh) Link to content: http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?direct=true&db=mnh&site=ehost-live&AN=18051884 More full text options: http://an5qy7ag4q.search.serialssolutions.com.libproxy.cc.stonybrook.edu?sid=CentralSearch:null&genre=article&atitle=%5BStudies+on+seeds+germination+and+seedlings+growth+of+Notopterygium+incisum%5D.&volume=32&issue=18&title=Zhongguo+Zhong+Yao+Za+Zhi+%3D+Zhongguo+Zhongyao+Zazhi+%3D+China+Journal+Of+Chinese+Materia+Medica&issn=1001-5302&date=2007-09-01&spage=1841&aulast=Shi&aufirst=J
5. ^ ^{a b} (2010, October 25) Notopterygium incisum. MDidea.com. Retrieved June 20, 2011, from http://www.mdidea.com/products/proper/proper072.html
6. ^ Zhang P; Yang XW. Studies on chemical constituents in roots and rhizomes of Notopterygium incisum. China Journal Of Chinese Materia Medica. 2008 Dec.Vol.33,Iss.24;p.2918-21 Source: MEDLINE (EBSCOhost) (http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=mnh) Link to content: http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?direct=true&db=mnh&site=ehost-live&AN=19294850 More full text options: http://an5qy7ag4q.search.serialssolutions.com.libproxy.cc.stonybrook.edu?sid=CentralSearch:null&genre=article&atitle=%5BStudies+on+chemical+constituents+in+roots+and+rhizomes+of+Notopterygium+incisum%5D.&volume=33&issue=24&title=Zhongguo+Zhong+Yao+Za+Zhi+%3D+Zhongguo+Zhongyao+Zazhi+%3D+China+Journal+Of+Chinese+Materia+Medica&issn=1001-5302&date=2008-12-01&spage=2918&aulast=Zhang&aufirst=P
7. ^ Wu SB; Pang F; Wen Y; Zhang HF; Zhao Z; Hu JF.Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines. Planta Medica. 2010 Jan.Vol.76,Iss.1;p.82-5 Source: MEDLINE (EBSCOhost) (http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=mnh) Link to content: http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?direct=true&db=mnh&site=ehost-live&AN=19653148 More full text options: http://an5qy7ag4q.search.serialssolutions.com.libproxy.cc.stonybrook.edu?sid=CentralSearch:null&genre=article&atitle=Antiproliferative+and+apoptotic+activities+of+linear+furocoumarins+from+Notopterygium+incisum+on+cancer+cell+lines.&volume=76&issue=1&title=Planta+Medica&issn=1439-0221&date=2010-01-01&spage=82&aulast=SB&aufirst=Wu
8. ^ Tomokazu Ohnuma; Takao Komatsu; Shinji Nakayama; Takahito Nishiyama; Kenichiro Ogura; Akira Hiratsuka. Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress. Archives of Biochemistry and Biophysics 2009.Vol.488,Iss.1;p.34 Source: ScienceDirect Journals (http://www.sciencedirect.com.libproxy.cc.stonybrook.edu) Link to content: http://www.sciencedirect.com.libproxy.cc.stonybrook.edu/science?_ob=GatewayURL&_method=citationSearch&_urlVersion=4&_origin=SERIALSCENT&_version=1&_uoikey=B6WB5-4WHFD7T-1&md5=a730aca26186730e9c0b68f89148b536 More full text options: http://an5qy7ag4q.search.serialssolutions.com.libproxy.cc.stonybrook.edu?sid=CentralSearch:null&genre=article&atitle=Induction+of+antioxidant+and+phase+2+drug-metabolizing+enzymes+by+falcarindiol+isolated+from+Notopterygium+incisum+extract%2C+which+activates+the+Nrf2%2FARE+pathway%2C+leads+to+cytoprotection+against+oxidative+and+electrophilic+stress&volume=488&issue=1&title=Archives+of+Biochemistry+and+Biophysics&date=2009-01-01&spage=34&aulast=Ohnuma&aufirst=Tomokazu
9. ^ Zschocke S; Lehner M; Bauer R. 5-Lipoxygenase and cyclooxygenase inhibitory active constituents from Qianghuo (Notopterygium incisum). Planta Medica. 1997 Jun.Vol.63,Iss.3;p.203-6 Source: MEDLINE (EBSCOhost) (http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=mnh) Link to content: http://search.ebscohost.com.libproxy.cc.stonybrook.edu/login.aspx?direct=true&db=mnh&site=ehost-live&AN=9265192 More full text options: http://an5qy7ag4q.search.serialssolutions.com.libproxy.cc.stonybrook.edu?sid=CentralSearch:null&genre=article&atitle=5-Lipoxygenase+and+cyclooxygenase+inhibitory+active+constituents+from+Qianghuo+%28Notopterygium+incisum%29.&volume=63&issue=3&title=Planta+Medica&issn=0032-0943&date=1997-06-01&spage=203&aulast=Zschocke&aufirst=S