Norbormide

Norbormide
Norbormide
Identifiers
CAS number 991-42-4
PubChem 24744067 (1R,7SYesY, 24840617 (6R,7RYesY, 12399560 YesY
ChemSpider 10468605 YesY
EC number 213-589-6
KEGG C19139 YesY
Jmol-3D images Image 1
Properties
Molecular formula C33H25N3O3
Molar mass 511.570
Hazards
Main hazards Toxic
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Norbormide (Raticate, Shoxin) is a toxic compound used as a rodenticide. It has several mechanisms of action, acting as a vasoconstrictor and calcium channel blocker,[1] but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.[2]

References

  1. ^ Rennison D, Bova S, Cavalli M, Ricchelli F, Zulian A, Hopkins B, Brimble MA. Synthesis and activity studies of analogues of the rat selective toxicant norbormide. Bioorganic and Medicinal Chemistry. 2007 Apr 15;15(8):2963-74. PMID 17321141
  2. ^ Zulian A, Petronilli V, Bova S, Dabbeni-Sala F, Cargnelli G, Cavalli M, Rennison D, Stäb J, Laita O, Lee DJ, Brimble MA, Hopkins B, Bernardi P, Ricchelli F. Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide. Biochimica et Biophysica Acta. 2007 Jul;1767(7):980-8. PMID 17509521