- NUT midline carcinoma
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NUT midline carcinoma Classification and external resources NUT midline carcinoma, abbreviated NMC, is a rare epithelial cancer that usually arises in the midline of the body and is characterized by a mutation in the nuclear protein in testis (NUT) gene.[1]
Contents
Symptoms
The symptoms are similar to other forms of cancer and dependent on the stage. Symptoms may include weight loss and fatigue.
NUT midline carcinomas are not specific to any tissue type or organ.[2] Common sites include the head, neck and mediastinum.[3]
Pathology
NMC morphologically are poorly differentiated carcinoma with islands of well-differentiated squamous epithelium.[2][3]
The differential diagnosis includes carcinoma ex pleomorphic adenoma and undifferentiated carcinoma.
The defining feature of NMCs is rearrangement of the NUT gene.[2] Most common is a translocation involving the BRD4 gene and NUT gene (t(15;19)(q13;p13.1)).[3][4]
Prognosis
The prognosis is poor.
See also
References
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ^ a b c French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ^ a b c French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ^ Online 'Mendelian Inheritance in Man' (OMIM) 608749
External Links
Categories:- Rare cancers
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