6-APB

6-APB
6-APB
Systematic (IUPAC) name
6-(2-aminopropyl)benzofuran
Clinical data
Pregnancy cat.  ?
Legal status Uncontrolled
Identifiers
CAS number 286834-85-3 YesY
286834-84-2 (hydrochloride)
ATC code None
PubChem CID 9794343
ChemSpider 7970110 YesY
Chemical data
Formula C11H13NO 
Mol. mass 175.23 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

6-(2-aminopropyl)benzofuran or 1-benzofuran-6-ylpropan-2-amine (6-APB) is thought to be a stimulant and entactogen drug although to date, no authoritative source can say even whether or not it is psychoactive. Chemically, it is of the phenethylamine and substituted amphetamine classes. It is similar to MDA in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. There is currently no toxicology data available.

Contents

Pharmacology

6-APB has not been properly assessed in terms of pharmacological action, but based on its chemical similarity to other amphetamines and methylenedioxy compounds, it likely acts as a releasing agent and reuptake inhibitor of serotonin, norepinephrine, and dopamine.[citation needed] Though its effects on monoamine release have not been validated, 6-APB has been claimed to act as an agonist of the 5-HT2C receptor.[1] It may also act as an agonist of the 5-HT2A and 5-HT2B receptors, the former likely explaining its reputed psychedelic effects.

Law

6-APB is unscheduled in the United States. However, this chemical may be covered under the Federal Analogue Act in the United States.

Certain countries contain a "substantially similar" catch-all clause in their drug law, such as New Zealand and Australia. This includes 6-APB as it is in some respects similar in chemical structure to the class A drug MDA, meaning 6-APB may be viewed as a controlled substance analogue in these jurisdictions.[2]

6-APB is unscheduled under the Controlled Drugs and Substances Act (CDSA) in Canada, although there is a Schedule III amphetamine analogue clause. Due to 6-APB's structure, it may be considered an analogue of MDA, but these types of offenses are rarely prosecuted.[citation needed] Canada's CDSA defines an analogue as any substance that, in relation to a controlled substance, has a substantially similar chemical structure.

6-APB is currently legal in the UK.

See also

References

  1. ^ US patent 7045545, Karin Briner et al, "Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists", published 2000-01-19, issued 2006-16-03 
  2. ^ "Misuse of Drugs Act 1975 New Zealand.". legislation.govt.nz. http://www.legislation.govt.nz/act/public/1975/0116/latest/DLM436101.html. Retrieved 2010-08-06. 

[Synthesis:http://www.xfactorchemicals.com/images/synthesis/6-apb-benzo-fury-synthesis-.html]


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