Pimagedine

Pimagedine
Pimagedine
IUPAC name
2-Aminoguanidine
Other names
Aminoguanidine; Guanyl hydrazine; Monoaminoguanidine; Hydrazinecarboximidamide; Imino semicarbazide
Identifiers
CAS number 79-17-4 YesY
PubChem 2146
ChEMBL CHEMBL225304 YesY
Jmol-3D images Image 1
Properties
Molecular formula CH6N4
Molar mass 74.09 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy.[1] Pimagedine is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products through interacting with 3-deoxyglucosone.

Aminoguanidines and their derivatives are also being developed for energetic material applications. Thorough combustion of aminoguanidines can produce voluminous non-toxic gases, at moderate temperatures, with a minimum of smoke or dust[2] . This characteristic favors application to explosive gas generators for automotive airbags, and solid-rocket propellants that generate high thrust per kilogram, while emitting minimal visible smoke or infrared radiation (useful militarily as well as to reduce environmental impact). Aminoguanidines can also be used as precursors for the synthesis of tetrazole-based energetic materials and drugs. [3]

References

  1. ^ W Kline Bolton, Emaad Abdel-Rahman (2002). "Pimagedine: a novel therapy for diabetic nephropathy". Expert Opinion on Investigational Drugs 11 (4): 565–574. doi:10.1517/13543784.11.4.565. PMID 11922864. 
  2. ^ Lundstrom,, Norman H.. "Monopropellant and propellant compositions including mono and polyaminoguanidine dinitrate". http://www.freepatentsonline.com/6045638.html. Retrieved 3/21/2011. 
  3. ^ Purchase Jr, Claude Forsey et al. "Tetrazole-substituted urea acat inhibitors". http://www.freepatentsonline.com/5362744.html. Retrieved 3/21/2011. 
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