Mixed-function oxidase

Mixed-function oxidase

Mixed-function oxidase is the name of a family of oxidase enzymes that catalyze a reaction in which each of the two atoms of oxygen in O2 is used for a different function in the reaction.[1]

Oxidase is a general name for enzymes that catalyze oxidations in which molecular oxygen is the electron acceptor but oxygen atoms do not appear in the oxidized product. Often, oxygen is reduced to either water (cytochrome oxidase of the mitochondrial electron transfer chain) or hydrogen peroxide (dehydrogenation of fatty acyl-CoA in peroxisomes). Most of the oxidases are flavoproteins.

The name "mixed-function oxidase" indicates that the enzyme oxidizes two different substrate simultaneously. Desaturation of fatty acyl-CoA in vertebrates is an example of the mixed-function oxidase reaction. In the process, saturated fatty acyl-CoA and NADPH are oxidized by molecular oxygen (O2) to produce monounsaturated fatty acyl-CoA, NADP+ and 2 molecules of water.

Reaction

The mixed-function oxidase reaction proceeds as follows:

AH + BH2 + O2 --> AOH + B + H2O

References



Wikimedia Foundation. 2010.

См. также в других словарях:

  • Mixed function oxidase — is the name of a family of oxidase enzymes which each of the two atoms of oxygen in O2 is used for a different function in the reaction. [MeshName|Mixed+Function+Oxygenases] Oxidase is a general name for enzymes that catalyze oxidations in which… …   Wikipedia

  • mixed function oxidase — monooxygenase …   Medical dictionary

  • Alternative oxidase — The alternative oxidase is an enzyme that forms part of the electron transport chain in plants, as well as some fungi, protists and possibly some animals. [cite journal |author=McDonald A, Vanlerberghe G |title=Branched mitochondrial electron… …   Wikipedia

  • Monoamine oxidase A — Ribbon diagram of an MAO A monomer, with FAD and clorgiline bound, oriented as if attached to the outer membrane of a mitochondrion …   Wikipedia

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Cytochrome P450 reductase — P450 (cytochrome) oxidoreductase PDB rendering based on 1amo …   Wikipedia

  • CYP3A4 — Cytochrome P450, family 3, subfamily A, polypeptide 4 Structure of CYP3A4 (from PDB 1W0E). Heme group visible at center …   Wikipedia

  • CYP1A2 — Cytochrome P450, family 1, subfamily A, polypeptide 2 PDB rendering based on 2hi4 …   Wikipedia

  • Analgesic nephropathy — Classification and external resources Classically caused by mixed analgesics containing phenacetin, analgesic nephropathy was once a common cause of acute kidney injury. ICD 10 N …   Wikipedia

  • CYP2C19 — Cytochrome P450 2C19 (abbreviated CYP2C19), a member of the cytochrome P450 mixed function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including… …   Wikipedia


Поделиться ссылкой на выделенное

Прямая ссылка:
Нажмите правой клавишей мыши и выберите «Копировать ссылку»