Mixed-field agglutination

Mixed-field agglutination

In transfusion medicine, mixed-field agglutination refers to mixed reactions during cell typing where two distinct cell populations are present: agglutinated cells admixed with many unagglutinated cells. The presence of two or more cell population is known as chimerism. Mixed-field agglutination is an important cause of ABO typing and genotype discrepancies. The cause of mixed field agglutinations should be sought prior to setting up blood for transfusion.[1]

Contents

Causes

False chimerism

By far the most common cause of mixed-field agglutination is false chimerism artificially induced through transfusion of identical donor red cells or through a stem cell transplant.[2][3] For example, a type B individual who has received massive transfusion of group O donor red cells may show mixed field agglutination with anti-B sera whereby his own group B red cells are agglutinated, while the group O donor red cells in his circulation are unagglutinated.

True chimerism

A true chimerism is a rare sporadic phenomenon whereby an individual has a dual cell population derived from more than one zygote. This may result from intrauterine exchange of erythrocyte precursors between twins (twin chimerism) or two fertilized eggs fuse into one individual. Twin chimerism results from mixing of blood between two twin fetuses through placental blood vessel anastomoses, leading to engraftment of hematopoietic stem cells from one twin within the marrow of the other. Each twin ends up with two distinct cell populations of varying proportions.

Reference

  1. ^ http://faculty.matcmadison.edu/mljensen/BloodBank/lectures/ABO%20discrepancies.htm
  2. ^ Roback, JD; Combs, MR; Grossman, BJ; Hillyer, CD. Technical Manual. AABB. 2008. pp353, 356.
  3. ^ Bluth MH, Reid ME, Manny N. Chimerism in the immunohematology laboratory in the molecular bioplogy era. Transfus Med Rev 2007;21:134-46.

Wikimedia Foundation. 2010.

См. также в других словарях:

  • test — 1. To prove; to try a substance; to determine the chemical nature of a substance by means of reagents. 2. A method of examination, as to determine the presence or absence of a definite disease or of some substance in any of the fluids, tissues,… …   Medical dictionary

  • Landsteiner , Karl — (1868–1943) Austrian–American pathologist Landsteiner, the son of a prominent Viennese journalist, was educated at the University of Vienna, where he obtained his MD in 1891. After studying chemistry in Germany under Emil Fischer and in… …   Scientists

  • Visceral leishmaniasis — Classification and external resources Amastigotes in a chorionic villus ICD 10 B …   Wikipedia

  • method — The mode or manner or orderly sequence of events of a process or procedure. SEE ALSO: fixative, operation, procedure, stain, technique. [G. methodos; fr. meta, after, + hodos, way] Abell Kendall m. a …   Medical dictionary

  • Mongoloid — redirects here. For the song by Devo, see Mongoloid (song). For the genetic disorder, see Down s Syndrome …   Wikipedia

  • language — /lang gwij/, n. 1. a body of words and the systems for their use common to a people who are of the same community or nation, the same geographical area, or the same cultural tradition: the two languages of Belgium; a Bantu language; the French… …   Universalium

  • Lunar soil — Moondust redirects here. For the Commodore 64 video game, see Moondust (video game). For the Psychoactive drug, see Phencyclidine. Bootprint on lunar soil …   Wikipedia

  • Norman Toponymy — refers to all place names in Normandy. Some belong to the common heritage of the Langue d oïl extension zone in northern France and Belgium; this is called Pre Normanic. Others contains Old Norse and Old English male names and toponymic… …   Wikipedia

  • Blood transfusion — Intervention Plastic bag containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution …   Wikipedia


Поделиться ссылкой на выделенное

Прямая ссылка:
Нажмите правой клавишей мыши и выберите «Копировать ссылку»