Gallamine triethiodide

Gallamine triethiodide
Gallamine triethiodide
Systematic (IUPAC) name
2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 65-29-2 YesY
ATC code M03AC02
PubChem CID 6172
IUPHAR ligand 356
DrugBank APRD00712
ChemSpider 5937 N
UNII Q3254X40X2 YesY
KEGG D02292 YesY
ChEBI CHEBI:503442 YesY
ChEMBL CHEMBL1200993 N
Chemical data
Formula C30H60N3O3+3 · 3 I- (gallamine triethiodide)
C24H45N3O3 (gallamine)
Mol. mass 891.529 g/mol (gallamine triethiodide)
423.633 g/mol
(gallamine)
SMILES eMolecules & PubChem
 N(what is this?)  triethiodide (verify)

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.[3]

References

  1. ^ "Webster's Online Dictionary - Flaxedil". http://www.websters-online-dictionary.org/Fl/Flaxedil.html. Retrieved 2008-12-15. 
  2. ^ "RxMed: Pharmaceutical Information - FLAXEDIL". http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20F)/FLAXEDIL.html. Retrieved 2008-12-15. 
  3. ^ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515. http://www.jrsm.org/cgi/pmidlookup?view=long&pmid=12091515. 
v · d · eSkeletal muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
NMJ block)
Curare alkaloids

ultra-short duration: Gantacurium

short duration: Mivacurium  • Chandonium

intermediate duration: Atracurium  • Cisatracurium  • Fazadinium  • Rocuronium  • Vecuronium

long duration: Doxacurium • Dimethyltubocurarine • Pancuronium • Pipecuronium  • Laudexium  • Gallamine

unsorted: Hexafluronium (Hexafluorenium)

Choline derivatives: Suxamethonium (Succinylcholine)

Polyalkylene derivatives: Hexamethonium
Centrally acting
Benzodiazepines
Anticholinergics (Antimuscarinics)
Other
Directly acting

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco(m, s, c)/cong(d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

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Look at other dictionaries:

  • gallamine triethiodide — noun Etymology: pyrogallol + amine + tri + eth + iodide Date: 1951 a substituted ammonium salt C30H60I3N3O3 that is used to produce muscle relaxation especially during anesthesia called also gallamine …   New Collegiate Dictionary

  • gallamine triethiodide — A triple quaternary ammonium compound with action comparable to that of curarine. * * * gal·la·mine tri·eth·io·dide gal ə .mēn .trī .eth ī ə .dīd n a substituted ammonium salt C30H60I3N3O3 that is used to produce muscle relaxation esp. during… …   Medical dictionary

  • gallamine triethiodide — ˈgaləˌmēn noun Etymology: gallamine from pyrogallol + amine : a substituted ammonium salt C6H3[OCH2CH2N(C2H5)3]3I3 derived from pyrogallol and used to produce muscle relaxation especially during anesthesia * * * /gal euh meen truy eth uy euh duyd …   Useful english dictionary

  • gallamine triethiodide — /gal euh meen truy eth uy euh duyd /, Pharm. a neuromuscular blocking drug, C30H60I3N3O3, similar to curare, used as a skeletal muscle relaxant in conjunction with surgical anesthesia. [(PYRO)GALL(OL) + AMINE; TRIETH(YL) + IODIDE] * * * …   Universalium

  • triethiodide — see GALLAMINE TRIETHIODIDE …   Medical dictionary

  • Gallamine — drugbox IUPAC name = N [2 [2,3 bis (2 diethylaminoethoxy) phenoxy] ethyl] N ethyl ethanamine CAS number = 65 29 2 ATC prefix = M03 ATC suffix = AC02 ATC supplemental = PubChem = 67425 DrugBank = APRD00712 chemical formula = C24H45N3O3… …   Wikipedia

  • gallamine — noun see gallamine triethiodide …   New Collegiate Dictionary

  • Flaxedil — noun neuromuscular blocking agent (trade name Flaxedil) used as a muscle relaxant in the administration of anesthesia • Syn: ↑gallamine • Usage Domain: ↑trade name • Hypernyms: ↑neuromuscular blocking agent, ↑muscle relaxant * * * …   Useful english dictionary

  • edrophonium chloride — A short duration competitive antagonist of skeletal muscle relaxants (curare derivatives and gallamine triethiodide) and an anticholinesterase, used as an antidote for curariform drugs, as a diagnostic agent in myasthenia gravis, and in …   Medical dictionary

  • Flaxedil — Flax·e·dil (flakґsə dil) trademark for a preparation of gallamine triethiodide …   Medical dictionary

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