Minichromosome maintenance


Minichromosome maintenance
MCM2/3/5 family
PDB 1ltl EBI.jpg
Structure of MCM from archaeal M. Thermoautotrophicum.[1]
Identifiers
Symbol MCM
Pfam PF00493
Pfam clan CL0023
InterPro IPR001208
SMART SM00350
PROSITE PDOC00662
Potential role of Cdc6 at the initiation of DNA replication.[2]

Mini Chromosome Maintenance complex, or Minichromosome Maintenance protein complex or mini-chromosome maintenance (MCM) 2-7 helicase complex has a role in both the initiation and the elongation phases of eukaryotic DNA replication, specifically the formation and elongation of the replication fork. MCM is a component of the pre-replication complex, which is a component of the licensing factor. MCM is a hexamer of six related polypeptides (mcm2-7) that form a ring structure.[3][4]

See also

References

  1. ^ Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS (March 2003). "The structure and function of MCM from archaeal M. Thermoautotrophicum". Nat. Struct. Biol. 10 (3): 160–7. doi:10.1038/nsb893. PMID 12548282. 
  2. ^ Borlado LR, Méndez J (February 2008). "CDC6: from DNA replication to cell cycle checkpoints and oncogenesis". Carcinogenesis 29 (2): 237–43. doi:10.1093/carcin/bgm268. PMID 18048387. 
  3. ^ a b Cortez D, Glick G, Elledge SJ (July 2004). "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases". Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10078–83. doi:10.1073/pnas.0403410101. PMC 454167. PMID 15210935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=454167. 
  4. ^ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM (April 2002). "Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus". J. Biol. Chem. 277 (14): 12118–27. doi:10.1074/jbc.M200091200. PMID 11821426. 

External links

Replication Termination see also DNA replication and repair-deficiency disorder
B bsyn: dna (repl, cycl, reco, repr· tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, )

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Look at other dictionaries:

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