Microantibody


Microantibody

A microantibody is an artificial short chain of amino acids copied from a fully functional natural antibody. Microantibodies can stop viruses such as HIV infecting cells in vitro.[1]

Antibodies are produced naturally by the body and play a key role in fighting infections caused by bacteria and viruses. They can also be used to treat infections by use of injections with blood plasma that contain large amounts of them.[2] But the use of whole, natural antibodies as medicines presents many problems: They can only be produced by live cells and this process is difficult to control on an industrial scale. They are large molecules and following administration by injection, they do not diffuse easily from the blood to the tissues and other sites of infections where they are needed.[3]

The use of microantibodies potentially solves these problems. They can be chemically synthesized and their small size allows them to leave the blood circulation quickly and reach the sites of infections in the tissues. They are also poorly immunogenic and do not stimulate an immune response in the host. Production problems remain, but microantibodies have the potential to become and important weapon in the arsenal used to treat infections and other diseases.[4]

Contents

Background

Vaccines are used to prevent infections by stimulating the body's immunity, which includes the production of antibodies that destroy infectious agents such as bacteria and viruses. But some infections can be prevented or treated by antibodies derived from others sources such as blood donations or monoclonal antibodies made in laboratories. This is called passive immunotherapy. However, these treatments have inherent problems: Passive antibody exposes the body to foreign protein and although monoclonal antibodies can be humanized[5] they can still invoke an immune response. However, only relatively small regions on antibody molecules are involved in the recognition and inactivation of pathogens. Microantibodies are smaller, synthetic molecules that mimic these regions but do not have the larger regions on antibodies that induce an immune response.[1]

Prototype

A microantibody has been made from a monoclonal antibody produced in mouse cells. This antibody inactivates HIV in vitro.[1]

See also

References

  1. ^ a b c Heap CJ, Wang Y, Pinheiro TJ, Reading SA, Jennings KR, Dimmock NJ (June 2005). "Analysis of a 17-amino acid residue, virus-neutralizing microantibody". The Journal of General Virology 86 (Pt 6): 1791–800. doi:10.1099/vir.0.80812-0. PMID 15914858. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=15914858. 
  2. ^ Rietveld E, Steyerberg EW, Polder JJ, Veeze HJ, Vergouwe Y, Huysman MW, de Groot R, Moll HA (July 2010). "Passive immunisation against respiratory syncytial virus: a cost-effectiveness analysis". Archives of Disease in Childhood 95 (7): 493–8. doi:10.1136/adc.2008.155556. PMID 20504841. http://adc.bmj.com/cgi/pmidlookup?view=long&pmid=20504841. 
  3. ^ Bakker JM, Bleeker WK, Parren PW (September 2004). "Therapeutic antibody gene transfer: an active approach to passive immunity". Molecular Therapy : the Journal of the American Society of Gene Therapy 10 (3): 411–6. doi:10.1016/j.ymthe.2004.06.865. PMID 15336642. 
  4. ^ Fujii I (November 2009). "[Beyond antibodies: generation of conformationally constrained peptides for molecular-targeting therapy"] (in Japanese). Yakugaku Zasshi 129 (11): 1303–9. PMID 19881201. http://joi.jlc.jst.go.jp/JST.JSTAGE/yakushi/129.1303?from=PubMed&lang=en. 
  5. ^ Cattaneo A (February 2010). "Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain". Current Opinion in Molecular Therapeutics 12 (1): 94–106. PMID 20140821. 

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