mir-6 microRNA precursor

mir-6 microRNA precursor
Predicted secondary structure and sequence conservation of mir-6
Identifiers
Symbol	mir-6
Rfam	RF00143
miRBase	MI0000124
miRBase family	MIPF0000119
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The mir-6 microRNA precursor appears to be specific to Drosophila species. In Drosophila melanogaster there are three microRNA precursors called dme-mir-6-1, dme-mir-6-2, dme-mir-6-3 that all give rise to identical mature microRNA sequences. Animal miRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The extents of the hairpin precursors are not generally known and are estimated based on hairpin prediction. The products are thought to have regulatory roles through complementarity to mRNA. The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference. miRNAs are numbered based on the sequence of the mature RNA.

References

• [1] Mourelatos, Z; Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev 16 (6): 720–728. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155365. 
• [2] Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 

External links

• Rfam page for mir-6 microRNA precursor
• miRBase entry for mir-6 related microRNAs