mir-166 microRNA precursor

mir-166 microRNA precursor
Predicted secondary structure and sequence conservation of mir-166
Identifiers
Symbol	mir-166
Rfam	RF00075
miRBase	MI0000201
miRBase family	MIPF0000004
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The plant mir-166 microRNA precursor is a small non-coding RNA gene. This microRNA (miRNA) has now been predicted or experimentally confirmed in a wide range of plant species.^[1] microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.^[2] In this case the mature sequence comes from the 3' arm of the precursor, and both Arabidopsis thaliana and rice genomes contain a number of related miRNA precursors which give rise to almost identical mature sequences.^[3] The mature products are thought to have regulatory roles through complementarity to messenger RNA.

References

1. ^ "miRNA gene family: MIR166". mirBASE. University of Manchester. http://www.mirbase.org/cgi-bin/mirna_summary.pl?fam=MIPF0000004. Retrieved 5 September 2011. 
2. ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 
3. ^ Reinhart, BJ; Weinstein EG, Rhoades MW, Bartel B, Bartel DP (2002). "MicroRNAs in plants". Genes Dev 16 (13): 1616–1626. doi:10.1101/gad.1004402. PMC 186362. PMID 12101121. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186362. 

External links

• Rfam page for mir-166 microRNA precursor
• MIPF0000004