Dermal equivalent

Dermal equivalent

The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on the surface to create a skin equivalent, or macrophages may be incorporated to model the inflammatory phase of wound healing [1].

References

  1. ^ Newton et al, Macrophages restrain contraction of an in vitro wound healing model http://www.springerlink.com/content/g518380278431706/



Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Wound healing — Hand abrasion …   Wikipedia

  • Collagen gel contraction assay — The collagen gel contraction assay is a type of wound contraction. It is performed using the dermal equivalent model, which consists of dermal fibroblasts seeded into a collagen gel.[1] References ^ Macrophages restrain contraction of an in vitro …   Wikipedia

  • angiosperm — /an jee euh sperrm /, n. Bot. a plant having its seeds enclosed in an ovary; a flowering plant. Cf. gymnosperm. [ANGIO + SPERM] * * * ▪ plant Introduction       any member of the more than 300,000 species of flowering plants (division Anthophyta) …   Universalium

  • Chromatophore — Zebrafish chromatophores mediate background adaptation on exposure to dark (top) and light environments (bottom). Chromatophores are pigment containing and light reflecting cells found in amphibians, fish, reptiles, crustaceans, and cephalopods.… …   Wikipedia

  • test — 1. To prove; to try a substance; to determine the chemical nature of a substance by means of reagents. 2. A method of examination, as to determine the presence or absence of a definite disease or of some substance in any of the fluids, tissues,… …   Medical dictionary

  • Chromatophore — Chromatophores de Poisson zèbre à l obscurité (au dessus) et à la lumière (en dessous). Les chromatophores sont des cellules pigmentaires ou réfléchissant la lumière prése …   Wikipédia en Français

  • Toxicity — This article is about the scientific term. For other uses of toxicity and toxic, see Toxicity (disambiguation). The skull and crossbones is a common symbol for toxicity. Toxicity is the degree to which a substance can damage a living or non… …   Wikipedia

  • Nerium — Oleander redirects here. For other uses, see Oleander (disambiguation). Nerium Nerium oleander in flower Scientific classification …   Wikipedia

  • bat — bat1 /bat/, n., v., batted, batting. n. 1. Sports. a. the wooden club used in certain games, as baseball and cricket, to strike the ball. b. a racket, esp. one used in badminton or table tennis. c. a whip used by a jockey. d. the act of using a… …   Universalium

  • reptile — reptilelike, adj. reptiloid /rep tl oyd /, adj. /rep til, tuyl/, n. 1. any cold blooded vertebrate of the class Reptilia, comprising the turtles, snakes, lizards, crocodilians, amphisbaenians, tuatara, and various extinct members including the… …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”