Dennie–Marfan syndrome


Dennie–Marfan syndrome

Dennie–Marfan syndrome is a syndrome in which there is association of spastic paraplegia of the lower limbs and mental retardation in children with congenital syphilis. Both sexes are affected, and the onset of the disease can be acute or insidious, with slow progression from weakness to quadriplegia. Epilepsy, cataract, and nystagmus may be also be found.

The syndrome was described by Charles Clayton Dennie in 1929, and Antoine Marfan in 1936.

External links

Dennie-Marfan syndrome at Who Named It?



Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Dennie-Marfan syndrome — Den·nie Mar·fan syndrome (denґe mahr făґ) [C.C. Dennie; Antoine Bernard Jean Marfan, French pediatrician, 1858–1947] see under syndrome …   Medical dictionary

  • Dennie-Marfan syndrome — spastic paralysis and mental retardation in association with congenital syphilis …   Medical dictionary

  • Antoine Marfan — Antoine Bernard Jean Marfan (June 23 1858 – 1942) was a French pediatrician. He was born in Castelnaudary (département Aude, Languedoc Roussillon) to Antoine Prosper and Adélaïde Thuries.He began his medical studies in Toulouse, where he stayed… …   Wikipedia

  • Charles Clayton Dennie — (1883 1971) was an American dermatologist remembered for Dennie Marfan syndrome and Dennie Morgan fold.[1] References ^ MORGAN DB (June 1948). A suggestive sign of allergy . Arch Derm Syphilol 57 (6): 1050. PMID 18098747 …   Wikipedia

  • Antoine Marfan — Portrait par Henry Bataille Bernard Jean Antonin Marfan, né à Castelnaudary (Aude) le 23 juin 1858 et mort à Paris le 11 février 1942, est un médecin pédiatre français, considéré comme l un des fondateurs de la pédiatrie en France …   Wikipédia en Français

  • Councilman body — (upper right) and ballooning degeneration (centre left). H E stain. In pathology, a Councilman body, also known as Councilman hyaline body, is an eosinophilic globule often found in the liver of individuals suffering …   Wikipedia

  • Clutton's joints — is a term describing the finding of symmetrical joint swelling seen in patients with congenital syphilis. It most commonly affects the knees, presenting with synovitis and joint effusions (collections of fluid within the joint capsules) lasting… …   Wikipedia

  • Negri bodies — Micrograph with numerous rabies virions (small dark grey rod like particles) and Negri bodies, larger pathognomonic cellular inclusions of rabies infection …   Wikipedia

  • Cowdry bodies — are eosinophilic nuclear inclusions composed of nucleic acid and protein seen in cells infected with Herpes simplex virus, Varicella zoster virus, and Cytomegalovirus. There are two types of intranuclear Cowdry bodies: Type A (as seen in herpes… …   Wikipedia

  • Inclusion body — Inclusion bodies are nuclear or cytoplasmic aggregates of stainable substances, usually proteins. They typically represent sites of viral multiplication in a bacterium or a eukaryotic cell and usually consist of viral capsid proteins. Inclusion… …   Wikipedia